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Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
Boezio AA, Copeland KW, Rex K, K Albrecht B, Bauer D, Bellon SF, Boezio C, Broome MA, Choquette D, Coxon A, Dussault I, Hirai S, Lewis R, Lin MH, Lohman J, Liu J, Peterson EA, Potashman M, Shimanovich R, Teffera Y, Whittington DA, Vaida KR, Harmange JC. Boezio AA, et al. Among authors: hirai s. J Med Chem. 2016 Mar 24;59(6):2328-42. doi: 10.1021/acs.jmedchem.5b01716. Epub 2016 Feb 11. J Med Chem. 2016. PMID: 26812066
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
Albrecht BK, Harmange JC, Bauer D, Berry L, Bode C, Boezio AA, Chen A, Choquette D, Dussault I, Fridrich C, Hirai S, Hoffman D, Larrow JF, Kaplan-Lefko P, Lin J, Lohman J, Long AM, Moriguchi J, O'Connor A, Potashman MH, Reese M, Rex K, Siegmund A, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Bellon SF. Albrecht BK, et al. Among authors: hirai s. J Med Chem. 2008 May 22;51(10):2879-82. doi: 10.1021/jm800043g. Epub 2008 Apr 22. J Med Chem. 2008. PMID: 18426196
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
Boezio AA, Berry L, Albrecht BK, Bauer D, Bellon SF, Bode C, Chen A, Choquette D, Dussault I, Fang M, Hirai S, Kaplan-Lefko P, Larrow JF, Lin MH, Lohman J, Potashman MH, Qu Y, Rex K, Santostefano M, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Harmange JC. Boezio AA, et al. Among authors: hirai s. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6307-12. doi: 10.1016/j.bmcl.2009.09.096. Epub 2009 Sep 27. Bioorg Med Chem Lett. 2009. PMID: 19819693
Risk Factors and Prevalence of Sleep Disturbance in Degenerative Cervical Myelopathy.
Nagata K, Nakamoto H, Iwai H, Takeshita Y, Hara N, Azuma S, Higashikawa A, Kawamura N, Oshina M, Hirai S, Masuda K, Sugita S, Ono T, Fukushima M, Nakajima K, Kato S, Taniguchi Y, Matsubayashi Y, Tanaka S, Oshima Y. Nagata K, et al. Among authors: hirai s. World Neurosurg. 2024 Dec 24:123610. doi: 10.1016/j.wneu.2024.123610. Online ahead of print. World Neurosurg. 2024. PMID: 39725286 Free article.
Postoperative Time-of-Flight Magnetic Resonance Angiography Classification is a Predictor of Postoperative Recanalization of Unruptured Cerebral Aneurysms.
Fujii S, Fujita K, Ishikawa M, Shigeta K, Aizawa Y, Yoshimura M, Hirota S, Ito K, Yoshino Y, Yamada K, Takahashi S, Sagawa H, Kinoshita Y, Kobayashi Y, Hirai S, Sumita K. Fujii S, et al. Among authors: hirai s. World Neurosurg. 2024 Dec 9;194:123496. doi: 10.1016/j.wneu.2024.11.079. Online ahead of print. World Neurosurg. 2024. PMID: 39579932 Free article.
An empirical model of soft bellows actuator.
Qiu Z, Zhang S, Xue Y, Zhang Y, Mori Y, Hirai S, Kawamura S, Wang Z. Qiu Z, et al. Among authors: hirai s. Sci Rep. 2024 Nov 19;14(1):28681. doi: 10.1038/s41598-024-79084-w. Sci Rep. 2024. PMID: 39562794 Free PMC article.
Assessment of environmental factors influencing SARS-CoV-2 in Vietnam's surface water across two years of clinical data.
Siri Y, Malla B, Thao LT, Hirai S, Ruti AA, Rahmani AF, Raya S, Angga MS, Sthapit N, Shrestha S, Takeda T, Kitajima M, Dinh NQ, Phuc PD, Ngo HTT, Haramoto E. Siri Y, et al. Among authors: hirai s. Sci Total Environ. 2024 Dec 20;957:177449. doi: 10.1016/j.scitotenv.2024.177449. Epub 2024 Nov 19. Sci Total Environ. 2024. PMID: 39542275 Free article.
1,270 results