He Y - Search Results

1

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.

He Y, Zeng MY, Yang D, Motro B, Núñez G. He Y, et al. Nature. 2016 Feb 18;530(7590):354-7. doi: 10.1038/nature16959. Epub 2016 Jan 27. Nature. 2016. PMID: 26814970 Free PMC article.

2

TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo.

He Y, Franchi L, Núñez G. He Y, et al. J Immunol. 2013 Jan 1;190(1):334-9. doi: 10.4049/jimmunol.1202737. Epub 2012 Dec 7. J Immunol. 2013. PMID: 23225887 Free PMC article.

3

The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages.

He Y, Franchi L, Núñez G. He Y, et al. Eur J Immunol. 2013 May;43(5):1147-52. doi: 10.1002/eji.201243187. Epub 2013 Mar 15. Eur J Immunol. 2013. PMID: 23401008 Free PMC article.

4

3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.

He Y, Varadarajan S, Muñoz-Planillo R, Burberry A, Nakamura Y, Núñez G. He Y, et al. J Biol Chem. 2014 Jan 10;289(2):1142-50. doi: 10.1074/jbc.M113.515080. Epub 2013 Nov 21. J Biol Chem. 2014. PMID: 24265316 Free PMC article.

5

Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.

Suzuki S, Franchi L, He Y, Muñoz-Planillo R, Mimuro H, Suzuki T, Sasakawa C, Núñez G. Suzuki S, et al. Among authors: he y. PLoS Pathog. 2014 Feb 6;10(2):e1003926. doi: 10.1371/journal.ppat.1003926. eCollection 2014 Feb. PLoS Pathog. 2014. PMID: 24516390 Free PMC article.

6

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.

Yang D, He Y, Muñoz-Planillo R, Liu Q, Núñez G. Yang D, et al. Among authors: he y. Immunity. 2015 Nov 17;43(5):923-32. doi: 10.1016/j.immuni.2015.10.009. Epub 2015 Nov 10. Immunity. 2015. PMID: 26572062 Free PMC article.

7

Mechanism and Regulation of NLRP3 Inflammasome Activation.

He Y, Hara H, Núñez G. He Y, et al. Trends Biochem Sci. 2016 Dec;41(12):1012-1021. doi: 10.1016/j.tibs.2016.09.002. Epub 2016 Sep 23. Trends Biochem Sci. 2016. PMID: 27669650 Free PMC article. Review.

8

RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly.

Duan Y, Zhang L, Angosto-Bazarra D, Pelegrín P, Núñez G, He Y. Duan Y, et al. Among authors: he y. Cell Rep. 2020 Nov 17;33(7):108405. doi: 10.1016/j.celrep.2020.108405. Cell Rep. 2020. PMID: 33207200 Free PMC article.

9

NEK7 phosphorylation amplifies NLRP3 inflammasome activation downstream of potassium efflux and gasdermin D.

Xu J, Zhang L, Duan Y, Sun F, Odeh N, He Y, Núñez G. Xu J, et al. Among authors: he y. Sci Immunol. 2025 Jan 3;10(103):eadl2993. doi: 10.1126/sciimmunol.adl2993. Epub 2025 Jan 3. Sci Immunol. 2025. PMID: 39752537

10

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation.

Kelley N, Jeltema D, Duan Y, He Y. Kelley N, et al. Among authors: he y. Int J Mol Sci. 2019 Jul 6;20(13):3328. doi: 10.3390/ijms20133328. Int J Mol Sci. 2019. PMID: 31284572 Free PMC article. Review.

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