Jung D - Search Results

1

Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models.

Sun JD, Liu Q, Ahluwalia D, Ferraro DJ, Wang Y, Jung D, Matteucci MD, Hart CP. Sun JD, et al. Among authors: jung d. Cancer Biol Ther. 2016 Apr 2;17(4):371-80. doi: 10.1080/15384047.2016.1139268. Epub 2016 Jan 28. Cancer Biol Ther. 2016. PMID: 26818215 Free PMC article. Clinical Trial.

2

Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.

Duan JX, Jiao H, Kaizerman J, Stanton T, Evans JW, Lan L, Lorente G, Banica M, Jung D, Wang J, Ma H, Li X, Yang Z, Hoffman RM, Ammons WS, Hart CP, Matteucci M. Duan JX, et al. Among authors: jung d. J Med Chem. 2008 Apr 24;51(8):2412-20. doi: 10.1021/jm701028q. Epub 2008 Feb 8. J Med Chem. 2008. PMID: 18257544 Free article.

3

14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.

Duan JX, Cai X, Meng F, Sun JD, Liu Q, Jung D, Jiao H, Matteucci J, Jung B, Bhupathi D, Ahluwalia D, Huang H, Hart CP, Matteucci M. Duan JX, et al. Among authors: jung b, jung d. J Med Chem. 2011 Mar 24;54(6):1715-23. doi: 10.1021/jm101354u. Epub 2011 Feb 22. J Med Chem. 2011. PMID: 21341674

4

Pharmacokinetics of TH-302: a hypoxically activated prodrug of bromo-isophosphoramide mustard in mice, rats, dogs and monkeys.

Jung D, Lin L, Jiao H, Cai X, Duan JX, Matteucci M. Jung D, et al. Cancer Chemother Pharmacol. 2012 Mar;69(3):643-54. doi: 10.1007/s00280-011-1741-6. Epub 2011 Oct 1. Cancer Chemother Pharmacol. 2012. PMID: 21964906

5

Metabolism, pharmacokinetics and excretion of a novel hypoxia activated cytotoxic prodrug, TH-302, in rats.

Jung D, Jiao H, Duan JX, Matteucci M, Wang R. Jung D, et al. Xenobiotica. 2012 Apr;42(4):372-88. doi: 10.3109/00498254.2011.622810. Epub 2011 Oct 17. Xenobiotica. 2012. PMID: 22004352

6

Metabolism and excretion of TH-302 in dogs.

Jung D, Jiao H, Duan JX, Matteucci M, Wang R. Jung D, et al. Xenobiotica. 2012 Jul;42(7):687-700. doi: 10.3109/00498254.2011.650234. Epub 2012 Feb 21. Xenobiotica. 2012. PMID: 22352389

7

A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug-Drug Interaction Potential of the Cytotoxic Prodrug Evofosfamide.

Lüpfert C, Dyroff M, von Richter O, Gallemann D, El Bawab S, Dolgos H, Jung D, Hecht S, Johne A. Lüpfert C, et al. Among authors: jung d. CPT Pharmacometrics Syst Pharmacol. 2018 Dec;7(12):829-837. doi: 10.1002/psp4.12360. Epub 2018 Oct 31. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 30311747 Free PMC article.

8

Enhanced pharmacological activities of AKR1C3-activated prodrug AST-3424 in cancer cells with defective DNA repair.

Meng F, Qi T, Liu X, Wang Y, Yu J, Lu Z, Cai X, Li A, Jung D, Duan J. Meng F, et al. Among authors: jung d. Int J Cancer. 2025 Jan 15;156(2):417-430. doi: 10.1002/ijc.35170. Epub 2024 Sep 7. Int J Cancer. 2025. PMID: 39243400 Free PMC article.

9

OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL.

Evans K, Duan J, Pritchard T, Jones CD, McDermott L, Gu Z, Toscan CE, El-Zein N, Mayoh C, Erickson SW, Guo Y, Meng F, Jung D, Rathi KS, Roberts KG, Mullighan CG, Shia CS, Pearce T, Teicher BA, Smith MA, Lock RB. Evans K, et al. Among authors: jung d. Clin Cancer Res. 2019 Jul 15;25(14):4493-4503. doi: 10.1158/1078-0432.CCR-19-0551. Epub 2019 Apr 23. Clin Cancer Res. 2019. PMID: 31015346 Free PMC article.

10

A novel selective AKR1C3-activated prodrug AST-3424/OBI-3424 exhibits broad anti-tumor activity.

Meng F, Li WF, Jung D, Wang CC, Qi T, Shia CS, Hsu RY, Hsieh YC, Duan J. Meng F, et al. Among authors: jung d. Am J Cancer Res. 2021 Jul 15;11(7):3645-3659. eCollection 2021. Am J Cancer Res. 2021. PMID: 34354865 Free PMC article.

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