Unacylated ghrelin normalizes skeletal muscle oxidative stress and prevents muscle catabolism by enhancing tissue mitophagy in experimental chronic kidney disease.
Gortan Cappellari G, Semolic A, Ruozi G, Vinci P, Guarnieri G, Bortolotti F, Barbetta D, Zanetti M, Giacca M, Barazzoni R.
Gortan Cappellari G, et al. Among authors: guarnieri g.
FASEB J. 2017 Dec;31(12):5159-5171. doi: 10.1096/fj.201700126R. Epub 2017 Aug 4.
FASEB J. 2017.
PMID: 28778977
Free article.
Here we show in a 5/6 nephrectomy (Nx) CKD rat model that 4 d s.c. UnAG administration (200 g twice a day) normalizes CKD-induced loss of gastrocnemius muscle mass and a cluster of high tissue mitochondrial reactive oxygen species generation, high proinflammatory cytokines …
Here we show in a 5/6 nephrectomy (Nx) CKD rat model that 4 d s.c. UnAG administration (200 g twice a day) normalizes CKD-induced los …