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Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression.
Piscuoglio S, Ng CK, Murray M, Burke KA, Edelweiss M, Geyer FC, Macedo GS, Inagaki A, Papanastasiou AD, Martelotto LG, Marchio C, Lim RS, Ioris RA, Nahar PK, Bruijn ID, Smyth L, Akram M, Ross D, Petrini JH, Norton L, Solit DB, Baselga J, Brogi E, Ladanyi M, Weigelt B, Reis-Filho JS. Piscuoglio S, et al. Among authors: akram m. J Pathol. 2016 Mar;238(4):508-18. doi: 10.1002/path.4672. Epub 2016 Jan 25. J Pathol. 2016. PMID: 26832993 Free PMC article.
MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast.
Piscuoglio S, Murray M, Fusco N, Marchiò C, Loo FL, Martelotto LG, Schultheis AM, Akram M, Weigelt B, Brogi E, Reis-Filho JS. Piscuoglio S, et al. Among authors: akram m. Histopathology. 2015 Nov;67(5):719-29. doi: 10.1111/his.12712. Epub 2015 May 24. Histopathology. 2015. PMID: 25855048 Free PMC article.
Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harbouring TP53 somatic mutations.
Guerini-Rocco E, Piscuoglio S, Ng CK, Geyer FC, De Filippo MR, Eberle CA, Akram M, Fusco N, Ichihara S, Sakr RA, Yatabe Y, Vincent-Salomon A, Rakha EA, Ellis IO, Wen YH, Weigelt B, Schnitt SJ, Reis-Filho JS. Guerini-Rocco E, et al. Among authors: akram m. J Pathol. 2016 Apr;238(5):677-88. doi: 10.1002/path.4691. J Pathol. 2016. PMID: 26806567 Free PMC article.
Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology.
Weisman PS, Ng CK, Brogi E, Eisenberg RE, Won HH, Piscuoglio S, De Filippo MR, Ioris R, Akram M, Norton L, Weigelt B, Berger MF, Reis-Filho JS, Wen HY. Weisman PS, et al. Among authors: akram m. Mod Pathol. 2016 May;29(5):476-88. doi: 10.1038/modpathol.2016.39. Epub 2016 Mar 4. Mod Pathol. 2016. PMID: 26939876 Free PMC article.
The Genomic Landscape of Male Breast Cancers.
Piscuoglio S, Ng CK, Murray MP, Guerini-Rocco E, Martelotto LG, Geyer FC, Bidard FC, Berman S, Fusco N, Sakr RA, Eberle CA, De Mattos-Arruda L, Macedo GS, Akram M, Baslan T, Hicks JB, King TA, Brogi E, Norton L, Weigelt B, Hudis CA, Reis-Filho JS. Piscuoglio S, et al. Among authors: akram m. Clin Cancer Res. 2016 Aug 15;22(16):4045-56. doi: 10.1158/1078-0432.CCR-15-2840. Epub 2016 Mar 9. Clin Cancer Res. 2016. PMID: 26960396 Free PMC article.
Mesothelin expression in triple negative breast carcinomas correlates significantly with basal-like phenotype, distant metastases and decreased survival.
Tozbikian G, Brogi E, Kadota K, Catalano J, Akram M, Patil S, Ho AY, Reis-Filho JS, Weigelt B, Norton L, Adusumilli PS, Wen HY. Tozbikian G, et al. Among authors: akram m. PLoS One. 2014 Dec 15;9(12):e114900. doi: 10.1371/journal.pone.0114900. eCollection 2014. PLoS One. 2014. PMID: 25506917 Free PMC article.
995 results