Kawamura S - Search Results

1

Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis.

Dawadi S, Kawamura S, Rubenstein A, Remmel R, Aldrich CC. Dawadi S, et al. Among authors: kawamura s. Bioorg Med Chem. 2016 Mar 15;24(6):1314-21. doi: 10.1016/j.bmc.2016.02.002. Epub 2016 Feb 3. Bioorg Med Chem. 2016. PMID: 26875934 Free PMC article.

2

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.

Quiroz RV, Reutershan MH, Schneider SE, Sloman D, Lacey BM, Swalm BM, Yeung CS, Gibeau C, Spellman DS, Rankic DA, Chen D, Witter D, Linn D, Munsell E, Feng G, Xu H, Hughes JME, Lim J, Saurí J, Geddes K, Wan M, Mansueto MS, Follmer NE, Fier PS, Siliphaivanh P, Daublain P, Palte RL, Hayes RP, Lee S, Kawamura S, Silverman S, Sanyal S, Henderson TJ, Ye Y, Gao Y, Nicholson B, Machacek MR. Quiroz RV, et al. Among authors: kawamura s. J Med Chem. 2021 Apr 8;64(7):3911-3939. doi: 10.1021/acs.jmedchem.0c02083. Epub 2021 Mar 23. J Med Chem. 2021. PMID: 33755451

3

Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones.

Kawamura S, Unno Y, Asai A, Arisawa M, Shuto S. Kawamura S, et al. Bioorg Med Chem. 2014 Jun 15;22(12):3091-5. doi: 10.1016/j.bmc.2014.04.032. Epub 2014 Apr 24. Bioorg Med Chem. 2014. PMID: 24814885

4

Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports.

Nakada K, Yoshikawa M, Ide S, Suemasa A, Kawamura S, Kobayashi T, Masuda E, Ito Y, Hayakawa W, Katayama T, Yamada S, Arisawa M, Minami M, Shuto S. Nakada K, et al. Among authors: kawamura s. Bioorg Med Chem. 2013 Sep 1;21(17):4938-50. doi: 10.1016/j.bmc.2013.06.063. Epub 2013 Jul 8. Bioorg Med Chem. 2013. PMID: 23886812 Free article.

5

Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity.

Kawamura S, Palte RL, Kim HY, Saurí J, Sondey C, Mansueto MS, Altman MD, Machacek MR. Kawamura S, et al. Bioorg Med Chem. 2022 Jul 15;66:116820. doi: 10.1016/j.bmc.2022.116820. Epub 2022 May 14. Bioorg Med Chem. 2022. PMID: 35594650

6

Investigation of the noncovalent binding mode of covalent proteasome inhibitors around the transition state by combined use of cyclopropylic strain-based conformational restriction and computational modeling.

Kawamura S, Unno Y, Tanaka M, Sasaki T, Yamano A, Hirokawa T, Kameda T, Asai A, Arisawa M, Shuto S. Kawamura S, et al. J Med Chem. 2013 Jul 25;56(14):5829-42. doi: 10.1021/jm400542h. Epub 2013 Jul 9. J Med Chem. 2013. PMID: 23837692

7

Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.

Kawamura S, Unno Y, Asai A, Arisawa M, Shuto S. Kawamura S, et al. J Med Chem. 2014 Mar 27;57(6):2726-35. doi: 10.1021/jm500045x. Epub 2014 Feb 25. J Med Chem. 2014. PMID: 24524217

8

Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action.

Kawamura S, Unno Y, List A, Mizuno A, Tanaka M, Sasaki T, Arisawa M, Asai A, Groll M, Shuto S. Kawamura S, et al. J Med Chem. 2013 May 9;56(9):3689-700. doi: 10.1021/jm4002296. Epub 2013 Apr 22. J Med Chem. 2013. PMID: 23547757

9

Identification of Potent Reverse Indazole Inhibitors for HPK1.

Yu EC, Methot JL, Fradera X, Lesburg CA, Lacey BM, Siliphaivanh P, Liu P, Smith DM, Xu Z, Piesvaux JA, Kawamura S, Xu H, Miller JR, Bittinger M, Pasternak A. Yu EC, et al. Among authors: kawamura s. ACS Med Chem Lett. 2021 Mar 1;12(3):459-466. doi: 10.1021/acsmedchemlett.0c00672. eCollection 2021 Mar 11. ACS Med Chem Lett. 2021. PMID: 33738073 Free PMC article.

10

Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand.

Kawamura S, Ito Y, Hirokawa T, Hikiyama E, Yamada S, Shuto S. Kawamura S, et al. J Med Chem. 2018 May 10;61(9):4020-4029. doi: 10.1021/acs.jmedchem.8b00041. Epub 2018 Apr 20. J Med Chem. 2018. PMID: 29652494

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