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Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability.
Dauber A, Muñoz-Calvo MT, Barrios V, Domené HM, Kloverpris S, Serra-Juhé C, Desikan V, Pozo J, Muzumdar R, Martos-Moreno GÁ, Hawkins F, Jasper HG, Conover CA, Frystyk J, Yakar S, Hwa V, Chowen JA, Oxvig C, Rosenfeld RG, Pérez-Jurado LA, Argente J. Dauber A, et al. Among authors: yakar s. EMBO Mol Med. 2016 Apr 1;8(4):363-74. doi: 10.15252/emmm.201506106. EMBO Mol Med. 2016. PMID: 26902202 Free PMC article.
Circulating levels of IGF-1 directly regulate bone growth and density.
Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D. Yakar S, et al. J Clin Invest. 2002 Sep;110(6):771-81. doi: 10.1172/JCI15463. J Clin Invest. 2002. PMID: 12235108 Free PMC article.
Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.
Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. Yakar S, et al. FASEB J. 2009 Mar;23(3):709-19. doi: 10.1096/fj.08-118976. Epub 2008 Oct 24. FASEB J. 2009. PMID: 18952711 Free PMC article.
Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences.
Domené HM, Hwa V, Argente J, Wit JM, Camacho-Hübner C, Jasper HG, Pozo J, van Duyvenvoorde HA, Yakar S, Fofanova-Gambetti OV, Rosenfeld RG; International ALS Collaborative Group. Domené HM, et al. Among authors: yakar s. Horm Res. 2009;72(3):129-41. doi: 10.1159/000232486. Epub 2009 Sep 1. Horm Res. 2009. PMID: 19729943 Review.
Unbound (bioavailable) IGF1 enhances somatic growth.
Elis S, Wu Y, Courtland HW, Cannata D, Sun H, Beth-On M, Liu C, Jasper H, Domené H, Karabatas L, Guida C, Basta-Pljakic J, Cardoso L, Rosen CJ, Frystyk J, Yakar S. Elis S, et al. Among authors: yakar s. Dis Model Mech. 2011 Sep;4(5):649-58. doi: 10.1242/dmm.006775. Epub 2011 May 31. Dis Model Mech. 2011. PMID: 21628395 Free PMC article.
Reductions in serum IGF-1 during aging impair health span.
Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW Jr, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S. Gong Z, et al. Among authors: yakar s. Aging Cell. 2014 Jun;13(3):408-18. doi: 10.1111/acel.12188. Epub 2013 Dec 30. Aging Cell. 2014. PMID: 24341939 Free PMC article.
Central effects of humanin on hepatic triglyceride secretion.
Gong Z, Su K, Cui L, Tas E, Zhang T, Dong HH, Yakar S, Muzumdar RH. Gong Z, et al. Among authors: yakar s. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E283-92. doi: 10.1152/ajpendo.00043.2015. Epub 2015 Jun 9. Am J Physiol Endocrinol Metab. 2015. PMID: 26058861 Free PMC article.
Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency.
Muñoz-Calvo MT, Barrios V, Pozo J, Chowen JA, Martos-Moreno GÁ, Hawkins F, Dauber A, Domené HM, Yakar S, Rosenfeld RG, Pérez-Jurado LA, Oxvig C, Frystyk J, Argente J. Muñoz-Calvo MT, et al. Among authors: yakar s. J Clin Endocrinol Metab. 2016 Nov;101(11):3879-3883. doi: 10.1210/jc.2016-2751. Epub 2016 Sep 20. J Clin Endocrinol Metab. 2016. PMID: 27648969 Free PMC article.
Growth Hormone Control of Hepatic Lipid Metabolism.
Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H, Yakar S. Liu Z, et al. Among authors: yakar s. Diabetes. 2016 Dec;65(12):3598-3609. doi: 10.2337/db16-0649. Epub 2016 Sep 27. Diabetes. 2016. PMID: 27679560 Free PMC article.
166 results