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From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.
Durieu E, Prina E, Leclercq O, Oumata N, Gaboriaud-Kolar N, Vougogiannopoulou K, Aulner N, Defontaine A, No JH, Ruchaud S, Skaltsounis AL, Galons H, Späth GF, Meijer L, Rachidi N. Durieu E, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2822-33. doi: 10.1128/AAC.00021-16. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26902771 Free PMC article.
Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth.
Efstathiou A, Gaboriaud-Kolar N, Myrianthopoulos V, Vougogiannopoulou K, Subota I, Aicher S, Mikros E, Bastin P, Skaltsounis AL, Soteriadou K, Smirlis D. Efstathiou A, et al. Among authors: gaboriaud kolar n. Antimicrob Agents Chemother. 2019 May 24;63(6):e02065-18. doi: 10.1128/AAC.02065-18. Print 2019 Jun. Antimicrob Agents Chemother. 2019. PMID: 30910902 Free PMC article.
An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3.
Efstathiou A, Gaboriaud-Kolar N, Smirlis D, Myrianthopoulos V, Vougogiannopoulou K, Alexandratos A, Kritsanida M, Mikros E, Soteriadou K, Skaltsounis AL. Efstathiou A, et al. Parasit Vectors. 2014 May 20;7:234. doi: 10.1186/1756-3305-7-234. Parasit Vectors. 2014. PMID: 24886176 Free PMC article.
Indirubin derivatives: a patent review (2010 - present).
Gaboriaud-Kolar N, Vougogiannopoulou K, Skaltsounis AL. Gaboriaud-Kolar N, et al. Expert Opin Ther Pat. 2015 May;25(5):583-93. doi: 10.1517/13543776.2015.1019865. Expert Opin Ther Pat. 2015. PMID: 25887337 Review.
Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents.
Efstathiou A, Meira CS, Gaboriaud-Kolar N, Bastos TM, Rocha VPC, Vougogiannopoulou K, Skaltsounis AL, Smirlis D, Soares MBP. Efstathiou A, et al. Among authors: gaboriaud kolar n. Virulence. 2018;9(1):1658-1668. doi: 10.1080/21505594.2018.1532242. Virulence. 2018. PMID: 30387370 Free PMC article.
Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.
Myrianthopoulos V, Kritsanida M, Gaboriaud-Kolar N, Magiatis P, Ferandin Y, Durieu E, Lozach O, Cappel D, Soundararajan M, Filippakopoulos P, Sherman W, Knapp S, Meijer L, Mikros E, Skaltsounis AL. Myrianthopoulos V, et al. ACS Med Chem Lett. 2013 Jan 10;4(1):22-26. doi: 10.1021/ml300207a. Epub 2012 Nov 1. ACS Med Chem Lett. 2013. PMID: 23336033 Free PMC article.
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