Vasquez G - Search Results

1

Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.

Prakash TP, Yu J, Migawa MT, Kinberger GA, Wan WB, Østergaard ME, Carty RL, Vasquez G, Low A, Chappell A, Schmidt K, Aghajan M, Crosby J, Murray HM, Booten SL, Hsiao J, Soriano A, Machemer T, Cauntay P, Burel SA, Murray SF, Gaus H, Graham MJ, Swayze EE, Seth PP. Prakash TP, et al. Among authors: vasquez g. J Med Chem. 2016 Mar 24;59(6):2718-33. doi: 10.1021/acs.jmedchem.5b01948. Epub 2016 Mar 9. J Med Chem. 2016. PMID: 26914862

2

2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.

Prakash TP, Manoharan M, Kawasaki AM, Lesnik EA, Owens SR, Vasquez G. Prakash TP, et al. Among authors: vasquez g. Org Lett. 2000 Dec 14;2(25):3995-8. doi: 10.1021/ol006555g. Org Lett. 2000. PMID: 11112626

3

Synthesis of 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl] modified nucleosides and oligonucleotides.

Prakash TP, Kawasaki AM, Fraser AS, Vasquez G, Manoharan M. Prakash TP, et al. Among authors: vasquez g. J Org Chem. 2002 Jan 25;67(2):357-69. doi: 10.1021/jo0103975. J Org Chem. 2002. PMID: 11798305

4

The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.

Lima WF, Rose JB, Nichols JG, Wu H, Migawa MT, Wyrzykiewicz TK, Vasquez G, Swayze EE, Crooke ST. Lima WF, et al. Among authors: vasquez g. Mol Pharmacol. 2007 Jan;71(1):73-82. doi: 10.1124/mol.106.025429. Epub 2006 Oct 6. Mol Pharmacol. 2007. PMID: 17028157

5

Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.

Hanessian S, Szychowski J, Adhikari SS, Vasquez G, Kandasamy P, Swayze EE, Migawa MT, Ranken R, François B, Wirmer-Bartoschek J, Kondo J, Westhof E. Hanessian S, et al. Among authors: vasquez g. J Med Chem. 2007 May 17;50(10):2352-69. doi: 10.1021/jm061200+. Epub 2007 Apr 26. J Med Chem. 2007. PMID: 17458946

6

Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Kinberger G, Migawa MT, Gaus H, Bhat B, Swayze EE. Seth PP, et al. Among authors: vasquez g. Nucleic Acids Symp Ser (Oxf). 2008;(52):553-4. doi: 10.1093/nass/nrn280. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776499

7

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Wancewicz EV, Witchell D, Swayze EE. Seth PP, et al. Among authors: vasquez g. J Med Chem. 2009 Jan 8;52(1):10-3. doi: 10.1021/jm801294h. J Med Chem. 2009. PMID: 19086780

8

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE. Seth PP, et al. Among authors: vasquez g. J Org Chem. 2010 Mar 5;75(5):1569-81. doi: 10.1021/jo902560f. J Org Chem. 2010. PMID: 20136157

9

Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides.

Seth PP, Allerson CR, Siwkowski A, Vasquez G, Berdeja A, Migawa MT, Gaus H, Prakash TP, Bhat B, Swayze EE. Seth PP, et al. Among authors: vasquez g. J Med Chem. 2010 Dec 9;53(23):8309-18. doi: 10.1021/jm101207e. Epub 2010 Nov 8. J Med Chem. 2010. PMID: 21058707

10

Synthesis and biophysical properties of constrained D-altritol nucleic acids (cANA).

Migawa MT, Prakash TP, Vasquez G, Seth PP, Swayze EE. Migawa MT, et al. Among authors: vasquez g. Org Lett. 2013 Sep 6;15(17):4316-9. doi: 10.1021/ol401730d. Epub 2013 Aug 13. Org Lett. 2013. PMID: 23937264

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