Iyer S - Search Results

1

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor.

Deng R, Bumbaca D, Pastuskovas CV, Boswell CA, West D, Cowan KJ, Chiu H, McBride J, Johnson C, Xin Y, Koeppen H, Leabman M, Iyer S. Deng R, et al. Among authors: iyer s. MAbs. 2016;8(3):593-603. doi: 10.1080/19420862.2015.1136043. Epub 2016 Feb 26. MAbs. 2016. PMID: 26918260 Free PMC article.

2

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

Deng R, Iyer S, Theil FP, Mortensen DL, Fielder PJ, Prabhu S. Deng R, et al. Among authors: iyer s. MAbs. 2011 Jan-Feb;3(1):61-6. doi: 10.4161/mabs.3.1.13799. Epub 2011 Jan 1. MAbs. 2011. PMID: 20962582 Free PMC article.

3

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys.

Leabman MK, Meng YG, Kelley RF, DeForge LE, Cowan KJ, Iyer S. Leabman MK, et al. Among authors: iyer s. MAbs. 2013 Nov-Dec;5(6):896-903. doi: 10.4161/mabs.26436. MAbs. 2013. PMID: 24492343 Free PMC article.

4

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys.

Deng R, Loyet KM, Lien S, Iyer S, DeForge LE, Theil FP, Lowman HB, Fielder PJ, Prabhu S. Deng R, et al. Among authors: iyer s. Drug Metab Dispos. 2010 Apr;38(4):600-5. doi: 10.1124/dmd.109.031310. Epub 2010 Jan 13. Drug Metab Dispos. 2010. PMID: 20071453 Clinical Trial.

5

Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?

Deng R, Jin F, Prabhu S, Iyer S. Deng R, et al. Among authors: iyer s. Expert Opin Drug Metab Toxicol. 2012 Feb;8(2):141-60. doi: 10.1517/17425255.2012.643868. Epub 2012 Jan 17. Expert Opin Drug Metab Toxicol. 2012. PMID: 22248267 Review.

6

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice.

Deng R, Meng YG, Hoyte K, Lutman J, Lu Y, Iyer S, DeForge LE, Theil FP, Fielder PJ, Prabhu S. Deng R, et al. Among authors: iyer s. MAbs. 2012 Jan-Feb;4(1):101-9. doi: 10.4161/mabs.4.1.18543. MAbs. 2012. PMID: 22327433 Free PMC article.

7

Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development.

Wang J, Iyer S, Fielder PJ, Davis JD, Deng R. Wang J, et al. Among authors: iyer s. Biopharm Drug Dispos. 2016 Mar;37(2):51-65. doi: 10.1002/bdd.1952. Epub 2015 May 15. Biopharm Drug Dispos. 2016. PMID: 25869767 Review.

8

Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies.

Mortensen DL, Prabhu S, Stefanich EG, Kadkhodayan-Fischer S, Gelzleichter TR, Baker D, Jiang J, Wallace K, Iyer S, Fielder PJ, Putnam WS. Mortensen DL, et al. Among authors: iyer s. MAbs. 2012 Nov-Dec;4(6):724-31. doi: 10.4161/mabs.22216. MAbs. 2012. PMID: 23778267 Free PMC article.

9

Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade.

Lin WY, Gong Q, Seshasayee D, Lin Z, Ou Q, Ye S, Suto E, Shu J, Lee WP, Lee CW, Fuh G, Leabman M, Iyer S, Howell K, Gelzleichter T, Beyer J, Danilenko D, Yeh S, DeForge LE, Ebens A, Thompson JS, Ambrose C, Balazs M, Starovasnik MA, Martin F. Lin WY, et al. Among authors: iyer s. Blood. 2007 Dec 1;110(12):3959-67. doi: 10.1182/blood-2007-04-088088. Epub 2007 Aug 8. Blood. 2007. PMID: 17687108 Free article.

10

Modeling approach to investigate the effect of neonatal Fc receptor binding affinity and anti-therapeutic antibody on the pharmacokinetic of humanized monoclonal anti-tumor necrosis factor-α IgG antibody in cynomolgus monkey.

Ng CM, Loyet KM, Iyer S, Fielder PJ, Deng R. Ng CM, et al. Among authors: iyer s. Eur J Pharm Sci. 2014 Jan 23;51:51-8. doi: 10.1016/j.ejps.2013.08.033. Epub 2013 Aug 31. Eur J Pharm Sci. 2014. PMID: 23999033

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