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Retargeting Strategies for Oncolytic Herpes Simplex Viruses.
Campadelli-Fiume G, Petrovic B, Leoni V, Gianni T, Avitabile E, Casiraghi C, Gatta V. Campadelli-Fiume G, et al. Among authors: gianni t. Viruses. 2016 Feb 26;8(3):63. doi: 10.3390/v8030063. Viruses. 2016. PMID: 26927159 Free PMC article. Review.
A heptad repeat in herpes simplex virus 1 gH, located downstream of the alpha-helix with attributes of a fusion peptide, is critical for virus entry and fusion.
Gianni T, Menotti L, Campadelli-Fiume G. Gianni T, et al. J Virol. 2005 Jun;79(11):7042-9. doi: 10.1128/JVI.79.11.7042-7049.2005. J Virol. 2005. PMID: 15890943 Free PMC article.
Recently, we reported that the ectodomain of HSV-1 gH carries a hydrophobic alpha-helix (residues 377 to 397) with attributes of an internal fusion peptide (T. Gianni, P. L. Martelli, R. Casadio, and G. Campadelli-Fiume, J. Virol. 79:2931-2940, 2005). ...
Recently, we reported that the ectodomain of HSV-1 gH carries a hydrophobic alpha-helix (residues 377 to 397) with attributes of an internal …
Hydrophobic alpha-helices 1 and 2 of herpes simplex virus gH interact with lipids, and their mimetic peptides enhance virus infection and fusion.
Gianni T, Fato R, Bergamini C, Lenaz G, Campadelli-Fiume G. Gianni T, et al. J Virol. 2006 Aug;80(16):8190-8. doi: 10.1128/JVI.00504-06. J Virol. 2006. PMID: 16873275 Free PMC article.
This contrasts with alpha-H1, which cannot be deleted and can be functionally replaced with heterologous fusion peptides (T. Gianni et al., J. Virol. 79:2931-2940, 2005). Synthetic peptides mimicking alpha-H1 and alpha-H2 induced fusion of nude lipid vesicles. ...
This contrasts with alpha-H1, which cannot be deleted and can be functionally replaced with heterologous fusion peptides (T. Giann …
The herpesvirus glycoproteins B and H.L are sequentially recruited to the receptor-bound gD to effect membrane fusion at virus entry.
Gianni T, Forghieri C, Campadelli-Fiume G. Gianni T, et al. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14572-7. doi: 10.1073/pnas.0606127103. Epub 2006 Sep 14. Proc Natl Acad Sci U S A. 2006. Retraction in: Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3668. doi: 10.1073/pnas.0700703104 PMID: 16973744 Free PMC article. Retracted.
47 results