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Sphingosine 1-phosphate and cancer.
Pyne NJ, Pyne S. Pyne NJ, et al. Among authors: pyne s. Nat Rev Cancer. 2010 Jul;10(7):489-503. doi: 10.1038/nrc2875. Epub 2010 Jun 17. Nat Rev Cancer. 2010. PMID: 20555359 Review.
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ. Tonelli F, et al. Among authors: pyne s, pyne nj. Cell Signal. 2010 Oct;22(10):1536-42. doi: 10.1016/j.cellsig.2010.05.022. Epub 2010 Jun 4. Cell Signal. 2010. PMID: 20570726 Free PMC article.
The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
Loveridge C, Tonelli F, Leclercq T, Lim KG, Long JS, Berdyshev E, Tate RJ, Natarajan V, Pitson SM, Pyne NJ, Pyne S. Loveridge C, et al. Among authors: pyne s, pyne nj. J Biol Chem. 2010 Dec 10;285(50):38841-52. doi: 10.1074/jbc.M110.127993. Epub 2010 Oct 6. J Biol Chem. 2010. PMID: 20926375 Free PMC article.
Targeting sphingosine kinase 1 in cancer.
Pyne NJ, Tonelli F, Lim KG, Long J, Edwards J, Pyne S. Pyne NJ, et al. Among authors: pyne s. Adv Biol Regul. 2012 Jan;52(1):31-8. doi: 10.1016/j.advenzreg.2011.07.001. Adv Biol Regul. 2012. PMID: 21791223 Review. No abstract available.
Sphingosine 1-phosphate signalling in cancer.
Pyne NJ, Tonelli F, Lim KG, Long JS, Edwards J, Pyne S. Pyne NJ, et al. Among authors: pyne s. Biochem Soc Trans. 2012 Feb;40(1):94-100. doi: 10.1042/BST20110602. Biochem Soc Trans. 2012. PMID: 22260672 Review.
428 results