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M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma.
Pisklakova A, McKenzie B, Zemp F, Lun X, Kenchappa RS, Etame AB, Rahman MM, Reilly K, Pilon-Thomas S, McFadden G, Kurz E, Forsyth PA. Pisklakova A, et al. Among authors: kenchappa rs. Neuro Oncol. 2016 Aug;18(8):1088-1098. doi: 10.1093/neuonc/now006. Epub 2016 Mar 8. Neuro Oncol. 2016. PMID: 26962017 Free PMC article.
In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells.
McKenzie BA, Zemp FJ, Pisklakova A, Narendran A, McFadden G, Lun X, Kenchappa RS, Kurz EU, Forsyth PA. McKenzie BA, et al. Among authors: kenchappa rs. Neuro Oncol. 2015 Aug;17(8):1086-94. doi: 10.1093/neuonc/nou359. Epub 2015 Jan 20. Neuro Oncol. 2015. PMID: 25605818 Free PMC article.
p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.
Forsyth PA, Krishna N, Lawn S, Valadez JG, Qu X, Fenstermacher DA, Fournier M, Potthast L, Chinnaiyan P, Gibney GT, Zeinieh M, Barker PA, Carter BD, Cooper MK, Kenchappa RS. Forsyth PA, et al. Among authors: kenchappa rs. J Biol Chem. 2014 Mar 21;289(12):8067-85. doi: 10.1074/jbc.M113.513762. Epub 2014 Feb 11. J Biol Chem. 2014. PMID: 24519935 Free PMC article.
Novel treatments for melanoma brain metastases.
Kenchappa RS, Tran N, Rao NG, Smalley KS, Gibney GT, Sondak VK, Forsyth PA. Kenchappa RS, et al. Cancer Control. 2013 Oct;20(4):298-306. doi: 10.1177/107327481302000407. Cancer Control. 2013. PMID: 24077406 Free article. Review.
37 results