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Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein.
Lanning ME, Yu W, Yap JL, Chauhan J, Chen L, Whiting E, Pidugu LS, Atkinson T, Bailey H, Li W, Roth BM, Hynicka L, Chesko K, Toth EA, Shapiro P, MacKerell AD Jr, Wilder PT, Fletcher S. Lanning ME, et al. Among authors: whiting e. Eur J Med Chem. 2016 May 4;113:273-92. doi: 10.1016/j.ejmech.2016.02.006. Epub 2016 Feb 4. Eur J Med Chem. 2016. PMID: 26985630 Free PMC article.
Discovery of Mcl-1 inhibitors based on a thiazolidine-2,4-dione scaffold.
Whiting E, Raje MR, Chauhan J, Wilder PT, Van Eker D, Hughes SJ, Bowen NG, Vickers GEA, Fenimore IC, Fletcher S. Whiting E, et al. Bioorg Med Chem Lett. 2018 Feb 1;28(3):523-528. doi: 10.1016/j.bmcl.2017.11.023. Epub 2017 Dec 12. Bioorg Med Chem Lett. 2018. PMID: 29329659
64 results