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Page 1
Carbachol dimers as homobivalent modulators of muscarinic receptors.
Matucci R, Nesi M, Martino MV, Bellucci C, Manetti D, Ciuti E, Mazzolari A, Dei S, Guandalini L, Teodori E, Vistoli G, Romanelli MN. Matucci R, et al. Among authors: nesi m. Biochem Pharmacol. 2016 May 15;108:90-101. doi: 10.1016/j.bcp.2016.03.012. Epub 2016 Mar 17. Biochem Pharmacol. 2016. PMID: 26996304
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.
Scapecchi S, Matucci R, Bellucci C, Buccioni M, Dei S, Guandalini L, Martelli C, Manetti D, Martini E, Marucci G, Nesi M, Romanelli MN, Teodori E, Gualtieri F. Scapecchi S, et al. Among authors: nesi m. J Med Chem. 2006 Mar 23;49(6):1925-31. doi: 10.1021/jm0510878. J Med Chem. 2006. PMID: 16539379
Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives.
Dei S, Bellucci C, Buccioni M, Ferraroni M, Guandalini L, Manetti D, Marucci G, Matucci R, Nesi M, Romanelli MN, Scapecchi S, Teodori E. Dei S, et al. Among authors: nesi m. Bioorg Med Chem. 2008 May 15;16(10):5490-500. doi: 10.1016/j.bmc.2008.04.013. Epub 2008 Apr 11. Bioorg Med Chem. 2008. PMID: 18455407
Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1).
Bonifazi A, Yano H, Del Bello F, Farande A, Quaglia W, Petrelli R, Matucci R, Nesi M, Vistoli G, Ferré S, Piergentili A. Bonifazi A, et al. Among authors: nesi m. J Med Chem. 2014 Nov 13;57(21):9065-77. doi: 10.1021/jm501173q. Epub 2014 Oct 16. J Med Chem. 2014. PMID: 25275964
63 results