Gregory KJ - Search Results

1

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.

Leach K, Gregory KJ, Kufareva I, Khajehali E, Cook AE, Abagyan R, Conigrave AD, Sexton PM, Christopoulos A. Leach K, et al. Among authors: gregory kj. Cell Res. 2016 May;26(5):574-92. doi: 10.1038/cr.2016.36. Epub 2016 Mar 22. Cell Res. 2016. PMID: 27002221 Free PMC article.

2

Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2.

Werry TD, Gregory KJ, Sexton PM, Christopoulos A. Werry TD, et al. Among authors: gregory kj. J Neurochem. 2005 Jun;93(6):1603-15. doi: 10.1111/j.1471-4159.2005.03161.x. J Neurochem. 2005. PMID: 15935077 Free article.

3

Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands.

Avlani VA, Gregory KJ, Morton CJ, Parker MW, Sexton PM, Christopoulos A. Avlani VA, et al. Among authors: gregory kj. J Biol Chem. 2007 Aug 31;282(35):25677-86. doi: 10.1074/jbc.M702311200. Epub 2007 Jun 25. J Biol Chem. 2007. PMID: 17591774 Free article.

4

A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

Valant C, Gregory KJ, Hall NE, Scammells PJ, Lew MJ, Sexton PM, Christopoulos A. Valant C, et al. Among authors: gregory kj. J Biol Chem. 2008 Oct 24;283(43):29312-21. doi: 10.1074/jbc.M803801200. Epub 2008 Aug 22. J Biol Chem. 2008. PMID: 18723515 Free PMC article.

5

Allosteric modulation of muscarinic acetylcholine receptors.

Gregory KJ, Sexton PM, Christopoulos A. Gregory KJ, et al. Curr Neuropharmacol. 2007 Sep;5(3):157-67. doi: 10.2174/157015907781695946. Curr Neuropharmacol. 2007. PMID: 19305798 Free PMC article.

6

Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias.

Gregory KJ, Hall NE, Tobin AB, Sexton PM, Christopoulos A. Gregory KJ, et al. J Biol Chem. 2010 Mar 5;285(10):7459-74. doi: 10.1074/jbc.M109.094011. Epub 2010 Jan 5. J Biol Chem. 2010. PMID: 20051519 Free PMC article.

7

Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.

Gregory KJ, Dong EN, Meiler J, Conn PJ. Gregory KJ, et al. Neuropharmacology. 2011 Jan;60(1):66-81. doi: 10.1016/j.neuropharm.2010.07.007. Epub 2010 Jul 14. Neuropharmacology. 2011. PMID: 20637216 Free PMC article. Review.

8

Allosteric modulation of metabotropic glutamate receptors.

Sheffler DJ, Gregory KJ, Rook JM, Conn PJ. Sheffler DJ, et al. Among authors: gregory kj. Adv Pharmacol. 2011;62:37-77. doi: 10.1016/B978-0-12-385952-5.00010-5. Adv Pharmacol. 2011. PMID: 21907906 Free PMC article. Review.

9

Overview of receptor allosterism.

Gregory KJ, Sexton PM, Christopoulos A. Gregory KJ, et al. Curr Protoc Pharmacol. 2010 Dec;Chapter 1:Unit 1.21. doi: 10.1002/0471141755.ph0121s51. Curr Protoc Pharmacol. 2010. PMID: 21935895

10

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.

Gregory KJ, Noetzel MJ, Rook JM, Vinson PN, Stauffer SR, Rodriguez AL, Emmitte KA, Zhou Y, Chun AC, Felts AS, Chauder BA, Lindsley CW, Niswender CM, Conn PJ. Gregory KJ, et al. Mol Pharmacol. 2012 Nov;82(5):860-75. doi: 10.1124/mol.112.080531. Epub 2012 Aug 3. Mol Pharmacol. 2012. PMID: 22863693 Free PMC article.

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