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Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis.
Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L. Castillo-Quan JI, et al. Among authors: hardy j. Cell Rep. 2016 Apr 19;15(3):638-650. doi: 10.1016/j.celrep.2016.03.041. Epub 2016 Apr 7. Cell Rep. 2016. PMID: 27068460 Free PMC article.
Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders.
Mencacci NE, Reynolds R, Ruiz SG, Vandrovcova J, Forabosco P, Sánchez-Ferrer A, Volpato V; UK Brain Expression Consortium; International Parkinson’s Disease Genomics Consortium; Weale ME, Bhatia KP, Webber C, Hardy J, Botía JA, Ryten M. Mencacci NE, et al. Among authors: hardy j. Brain. 2020 Sep 1;143(9):2771-2787. doi: 10.1093/brain/awaa217. Brain. 2020. PMID: 32889528 Free PMC article.
Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset.
Billingsley KJ, Barbosa IA, Bandrés-Ciga S, Quinn JP, Bubb VJ, Deshpande C, Botia JA, Reynolds RH, Zhang D, Simpson MA, Blauwendraat C, Gan-Or Z, Gibbs JR, Nalls MA, Singleton A; International Parkinson’s Disease Genomics Consortium (IPDGC); Ryten M, Koks S. Billingsley KJ, et al. NPJ Parkinsons Dis. 2019 May 22;5:8. doi: 10.1038/s41531-019-0080-x. eCollection 2019. NPJ Parkinsons Dis. 2019. PMID: 31123700 Free PMC article.
THAP1 mutations (DYT6) are an additional cause of early-onset dystonia.
Houlden H, Schneider SA, Paudel R, Melchers A, Schwingenschuh P, Edwards M, Hardy J, Bhatia KP. Houlden H, et al. Among authors: hardy j. Neurology. 2010 Mar 9;74(10):846-50. doi: 10.1212/WNL.0b013e3181d5276d. Neurology. 2010. PMID: 20211909 Free PMC article.
Review: genetics and neuropathology of primary pure dystonia.
Paudel R, Hardy J, Revesz T, Holton JL, Houlden H. Paudel R, et al. Among authors: hardy j. Neuropathol Appl Neurobiol. 2012 Oct;38(6):520-34. doi: 10.1111/j.1365-2990.2012.01298.x. Neuropathol Appl Neurobiol. 2012. PMID: 22897341 Review.
3,494 results