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Libertas: a phase II placebo-controlled study of NRL001 in patients with faecal incontinence showed an unexpected and sustained placebo response.
Siproudhis L, Graf W, Emmanuel A, Walker D, Shing RN, Pediconi C, Pilot J, Wexner S, Scholefield J. Siproudhis L, et al. Among authors: shing rn. Int J Colorectal Dis. 2016 Jun;31(6):1205-16. doi: 10.1007/s00384-016-2585-7. Epub 2016 Apr 13. Int J Colorectal Dis. 2016. PMID: 27075314 Free PMC article. Clinical Trial.
Libertas: rationale and study design of a multicentre, Phase II, double-blind, randomised, placebo-controlled investigation to evaluate the efficacy, safety and tolerability of locally applied NRL001 in patients with faecal incontinence.
Siproudhis L, Jones D, Shing RN, Walker D, Scholefield JH; Libertas Study Consortium. Siproudhis L, et al. Among authors: shing rn. Colorectal Dis. 2014 Mar;16 Suppl 1:59-66. doi: 10.1111/codi.12546. Colorectal Dis. 2014. PMID: 24499497 Clinical Trial.