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Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.
Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A. Fraser C, et al. Among authors: harrington l. J Med Chem. 2016 May 26;59(10):4697-710. doi: 10.1021/acs.jmedchem.6b00065. Epub 2016 May 4. J Med Chem. 2016. PMID: 27115835 Free PMC article.
Cancer: Trouble upstream.
Patton EE, Harrington L. Patton EE, et al. Among authors: harrington l. Nature. 2013 Mar 21;495(7441):320-1. doi: 10.1038/495320a. Nature. 2013. PMID: 23518559 No abstract available.
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Dolma S, Selvadurai HJ, Lan X, Lee L, Kushida M, Voisin V, Whetstone H, So M, Aviv T, Park N, Zhu X, Xu C, Head R, Rowland KJ, Bernstein M, Clarke ID, Bader G, Harrington L, Brumell JH, Tyers M, Dirks PB. Dolma S, et al. Among authors: harrington l. Cancer Cell. 2016 Jun 13;29(6):859-873. doi: 10.1016/j.ccell.2016.05.002. Cancer Cell. 2016. PMID: 27300435 Free PMC article.
Targeted protein degradation as a tumor suppressor.
Arat NO, Harrington L. Arat NO, et al. Among authors: harrington l. Cell Cycle. 2014;13(22):3473. doi: 10.4161/15384101.2014.980700. Cell Cycle. 2014. PMID: 25493413 Free PMC article. No abstract available.
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.
Benslimane Y, Sánchez-Osuna M, Coulombe-Huntington J, Bertomeu T, Henry D, Huard C, Bonneil É, Thibault P, Tyers M, Harrington L. Benslimane Y, et al. Among authors: harrington l. Aging Cell. 2021 Apr;20(4):e13331. doi: 10.1111/acel.13331. Epub 2021 Mar 4. Aging Cell. 2021. PMID: 33660365 Free PMC article.
Reconstitution of human telomerase activity in vitro.
Beattie TL, Zhou W, Robinson MO, Harrington L. Beattie TL, et al. Among authors: harrington l. Curr Biol. 1998 Jan 29;8(3):177-80. doi: 10.1016/s0960-9822(98)70067-3. Curr Biol. 1998. PMID: 9443919 Free article.
640 results