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Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.
Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A. Fraser C, et al. Among authors: patton ee. J Med Chem. 2016 May 26;59(10):4697-710. doi: 10.1021/acs.jmedchem.6b00065. Epub 2016 May 4. J Med Chem. 2016. PMID: 27115835 Free PMC article.
Cancer: Trouble upstream.
Patton EE, Harrington L. Patton EE, et al. Nature. 2013 Mar 21;495(7441):320-1. doi: 10.1038/495320a. Nature. 2013. PMID: 23518559 No abstract available.
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
Sarvi S, Crispin R, Lu Y, Zeng L, Hurley TD, Houston DR, von Kriegsheim A, Chen CH, Mochly-Rosen D, Ranzani M, Mathers ME, Xu X, Xu W, Adams DJ, Carragher NO, Fujita M, Schuchter L, Unciti-Broceta A, Brunton VG, Patton EE. Sarvi S, et al. Among authors: patton ee. Cell Chem Biol. 2018 Dec 20;25(12):1456-1469.e6. doi: 10.1016/j.chembiol.2018.09.005. Epub 2018 Oct 4. Cell Chem Biol. 2018. PMID: 30293938 Free PMC article.
PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation.
Johansson JA, Marie KL, Lu Y, Brombin A, Santoriello C, Zeng Z, Zich J, Gautier P, von Kriegsheim A, Brunsdon H, Wheeler AP, Dreger M, Houston DR, Dooley CM, Sims AH, Busch-Nentwich EM, Zon LI, Illingworth RS, Patton EE. Johansson JA, et al. Among authors: patton ee. Dev Cell. 2020 Aug 10;54(3):317-332.e9. doi: 10.1016/j.devcel.2020.06.013. Epub 2020 Jul 10. Dev Cell. 2020. PMID: 32652076 Free PMC article.
MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish.
Lundegaard PR, Anastasaki C, Grant NJ, Sillito RR, Zich J, Zeng Z, Paranthaman K, Larsen AP, Armstrong JD, Porteous DJ, Patton EE. Lundegaard PR, et al. Among authors: patton ee. Chem Biol. 2015 Oct 22;22(10):1335-46. doi: 10.1016/j.chembiol.2015.08.010. Epub 2015 Sep 17. Chem Biol. 2015. PMID: 26388333 Free PMC article.
Bright insights into palladium-triggered local chemotherapy.
Bray TL, Salji M, Brombin A, Pérez-López AM, Rubio-Ruiz B, Galbraith LCA, Patton EE, Leung HY, Unciti-Broceta A. Bray TL, et al. Among authors: patton ee. Chem Sci. 2018 Jul 17;9(37):7354-7361. doi: 10.1039/c8sc02291g. eCollection 2018 Oct 7. Chem Sci. 2018. PMID: 30542538 Free PMC article.
103 results