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Di-fluoro azepane HBV capsid assembly modulators.
DeRatt LG, Stoops B, Shaffer P, Lam AM, Espiritu C, Vogel R, Lau V, Flores OA, Kuduk SD. DeRatt LG, et al. Among authors: espiritu c. Bioorg Med Chem Lett. 2023 Aug 15;92:129350. doi: 10.1016/j.bmcl.2023.129350. Epub 2023 May 27. Bioorg Med Chem Lett. 2023. PMID: 37247697
SEC14L2 enables pan-genotype HCV replication in cell culture.
Saeed M, Andreo U, Chung HY, Espiritu C, Branch AD, Silva JM, Rice CM. Saeed M, et al. Among authors: espiritu c. Nature. 2015 Aug 27;524(7566):471-5. doi: 10.1038/nature14899. Epub 2015 Aug 12. Nature. 2015. PMID: 26266980 Free PMC article.
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA. Lam AM, et al. Among authors: espiritu c. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. doi: 10.1128/AAC.00399-10. Epub 2010 Jun 1. Antimicrob Agents Chemother. 2010. PMID: 20516278 Free PMC article.
Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.
Murakami E, Tolstykh T, Bao H, Niu C, Steuer HM, Bao D, Chang W, Espiritu C, Bansal S, Lam AM, Otto MJ, Sofia MJ, Furman PA. Murakami E, et al. Among authors: espiritu c. J Biol Chem. 2010 Nov 5;285(45):34337-47. doi: 10.1074/jbc.M110.161802. Epub 2010 Aug 26. J Biol Chem. 2010. PMID: 20801890 Free PMC article.
64 results