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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.
Bell CC, Hendriks DF, Moro SM, Ellis E, Walsh J, Renblom A, Fredriksson Puigvert L, Dankers AC, Jacobs F, Snoeys J, Sison-Young RL, Jenkins RE, Nordling Å, Mkrtchian S, Park BK, Kitteringham NR, Goldring CE, Lauschke VM, Ingelman-Sundberg M. Bell CC, et al. Among authors: jacobs f. Sci Rep. 2016 May 4;6:25187. doi: 10.1038/srep25187. Sci Rep. 2016. PMID: 27143246 Free PMC article.
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.
Bell CC, Dankers ACA, Lauschke VM, Sison-Young R, Jenkins R, Rowe C, Goldring CE, Park K, Regan SL, Walker T, Schofield C, Baze A, Foster AJ, Williams DP, van de Ven AWM, Jacobs F, Houdt JV, Lähteenmäki T, Snoeys J, Juhila S, Richert L, Ingelman-Sundberg M. Bell CC, et al. Among authors: jacobs f. Toxicol Sci. 2018 Apr 1;162(2):655-666. doi: 10.1093/toxsci/kfx289. Toxicol Sci. 2018. PMID: 29329425 Free PMC article.
Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters.
Ahmad A, Ogungbenro K, Kunze A, Jacobs F, Snoeys J, Rostami-Hodjegan A, Galetin A. Ahmad A, et al. Among authors: jacobs f. CPT Pharmacometrics Syst Pharmacol. 2021 May;10(5):467-477. doi: 10.1002/psp4.12610. Epub 2021 May 1. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33704919 Free PMC article. Clinical Trial.
Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug-Drug Interactions.
Willemin ME, Van Der Made TK, Pijpers I, Dillen L, Kunze A, Jonkers S, Steemans K, Tuytelaars A, Jacobs F, Monshouwer M, Scotcher D, Rostami-Hodjegan A, Galetin A, Snoeys J. Willemin ME, et al. Among authors: jacobs f. Clin Pharmacokinet. 2021 Sep;60(9):1187-1199. doi: 10.1007/s40262-021-01004-2. Epub 2021 Apr 10. Clin Pharmacokinet. 2021. PMID: 33840062 Clinical Trial.
622 results