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IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD.
Chen J, Kieswich JE, Chiazza F, Moyes AJ, Gobbetti T, Purvis GS, Salvatori DC, Patel NS, Perretti M, Hobbs AJ, Collino M, Yaqoob MM, Thiemermann C. Chen J, et al. J Am Soc Nephrol. 2017 Jan;28(1):94-105. doi: 10.1681/ASN.2015060670. Epub 2016 May 6. J Am Soc Nephrol. 2017. PMID: 27153924 Free PMC article.
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.
Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C, Perretti M. Gobbetti T, et al. Among authors: chen j. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18685-90. doi: 10.1073/pnas.1410938111. Epub 2014 Dec 15. Proc Natl Acad Sci U S A. 2014. PMID: 25512512 Free PMC article.
The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men.
Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J, Marx G, Jacobs M, Thiemermann C, Schuerholz T. Martin L, et al. Among authors: chen j. Front Immunol. 2017 Jun 12;8:681. doi: 10.3389/fimmu.2017.00681. eCollection 2017. Front Immunol. 2017. PMID: 28659919 Free PMC article.
Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes.
Purvis GSD, Chiazza F, Chen J, Azevedo-Loiola R, Martin L, Kusters DHM, Reutelingsperger C, Fountoulakis N, Gnudi L, Yaqoob MM, Collino M, Thiemermann C, Solito E. Purvis GSD, et al. Among authors: chen j. Diabetologia. 2018 Feb;61(2):482-495. doi: 10.1007/s00125-017-4469-y. Epub 2017 Oct 30. Diabetologia. 2018. PMID: 29085990 Free PMC article.
Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis.
Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C, Ahluwalia A. Chen J, et al. FASEB J. 2018 Jul;32(7):3816-3831. doi: 10.1096/fj.201701303R. Epub 2018 Feb 20. FASEB J. 2018. PMID: 29465314
In sum activation of TRPV1 by 20-HETE leads to the release of CGRP, which protects the heart against the cardiac dysfunction in endotoxemia and identifies both TRPV1 and CGRP receptors as potential therapeutic targets in endotoxemia.-Chen, J., Hamers, A. J. P …
In sum activation of TRPV1 by 20-HETE leads to the release of CGRP, which protects the heart against the cardiac dysfunction in endotoxemia …
A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.
Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C, Yaqoob MM. Kieswich JE, et al. Among authors: chen j. BMC Nephrol. 2018 Dec 4;19(1):346. doi: 10.1186/s12882-018-1155-3. BMC Nephrol. 2018. PMID: 30509210 Free PMC article.
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