Wang Y - Search Results

1

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys.

Shemesh CS, Yu RZ, Gaus HJ, Greenlee S, Post N, Schmidt K, Migawa MT, Seth PP, Zanardi TA, Prakash TP, Swayze EE, Henry SP, Wang Y. Shemesh CS, et al. Among authors: wang y. Mol Ther Nucleic Acids. 2016 May 10;5(5):e319. doi: 10.1038/mtna.2016.31. Mol Ther Nucleic Acids. 2016. PMID: 27164023 Free PMC article.

2

Assessment of the Drug Interaction Potential of Unconjugated and GalNAc₃-Conjugated 2'-MOE-ASOs.

Shemesh CS, Yu RZ, Warren MS, Liu M, Jahic M, Nichols B, Post N, Lin S, Norris DA, Hurh E, Huang J, Watanabe T, Henry SP, Wang Y. Shemesh CS, et al. Among authors: wang y. Mol Ther Nucleic Acids. 2017 Dec 15;9:34-47. doi: 10.1016/j.omtn.2017.08.012. Epub 2017 Aug 30. Mol Ther Nucleic Acids. 2017. PMID: 29246313 Free PMC article.

3

Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc₃-Conjugated Antisense Oligonucleotides.

Wang Y, Yu RZ, Henry S, Geary RS. Wang Y, et al. Expert Opin Drug Metab Toxicol. 2019 Jun;15(6):475-485. doi: 10.1080/17425255.2019.1621838. Epub 2019 May 30. Expert Opin Drug Metab Toxicol. 2019. PMID: 31144994 Review.

4

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice.

Shemesh CS, Yu RZ, Gaus HJ, Seth PP, Swayze EE, Bennett FC, Geary RS, Henry SP, Wang Y. Shemesh CS, et al. Among authors: wang y. Nucleic Acid Ther. 2016 Aug;26(4):223-35. doi: 10.1089/nat.2016.0607. Epub 2016 Mar 31. Nucleic Acid Ther. 2016. PMID: 27031383

5

Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice.

Yu RZ, Graham MJ, Post N, Riney S, Zanardi T, Hall S, Burkey J, Shemesh CS, Prakash TP, Seth PP, Swayze EE, Geary RS, Wang Y, Henry S. Yu RZ, et al. Among authors: wang y. Mol Ther Nucleic Acids. 2016 May 3;5(5):e317. doi: 10.1038/mtna.2016.26. Mol Ther Nucleic Acids. 2016. PMID: 27138177 Free PMC article.

6

Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.

Yu RZ, Gunawan R, Post N, Zanardi T, Hall S, Burkey J, Kim TW, Graham MJ, Prakash TP, Seth PP, Swayze EE, Geary RS, Henry SP, Wang Y. Yu RZ, et al. Among authors: wang y. Nucleic Acid Ther. 2016 Dec;26(6):372-380. doi: 10.1089/nat.2016.0623. Epub 2016 Aug 8. Nucleic Acid Ther. 2016. PMID: 27500733

7

Lack of QT Prolongation for 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects.

Yu RZ, Gunawan R, Geary RS, Hughes SG, Henry SP, Wang Y. Yu RZ, et al. Among authors: wang y. Nucleic Acid Ther. 2017 Oct;27(5):285-294. doi: 10.1089/nat.2017.0676. Epub 2017 Aug 11. Nucleic Acid Ther. 2017. PMID: 28799823 Free PMC article. Clinical Trial.

8

Integrated Assessment of the Clinical Performance of GalNAc₃-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.

Crooke ST, Baker BF, Xia S, Yu RZ, Viney NJ, Wang Y, Tsimikas S, Geary RS. Crooke ST, et al. Among authors: wang y. Nucleic Acid Ther. 2019 Feb;29(1):16-32. doi: 10.1089/nat.2018.0753. Epub 2018 Dec 20. Nucleic Acid Ther. 2019. PMID: 30570431 Free PMC article. Clinical Trial.

9

Metabolism and Disposition of Volanesorsen, a 2'-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species.

Post N, Yu R, Greenlee S, Gaus H, Hurh E, Matson J, Wang Y. Post N, et al. Among authors: wang y. Drug Metab Dispos. 2019 Oct;47(10):1164-1173. doi: 10.1124/dmd.119.087395. Epub 2019 Jul 26. Drug Metab Dispos. 2019. PMID: 31350288 Clinical Trial.

10

Bioanalysis considerations on the pharmacokinetic evaluation of antisense therapeutics.

Norris DA, Post N, Yu RZ, Greenlee S, Wang Y. Norris DA, et al. Among authors: wang y. Bioanalysis. 2019 Nov;11(21):1909-1912. doi: 10.4155/bio-2019-0194. Epub 2019 Oct 25. Bioanalysis. 2019. PMID: 31648523 No abstract available.

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