Zanardi TA - Search Results

1

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys.

Shemesh CS, Yu RZ, Gaus HJ, Greenlee S, Post N, Schmidt K, Migawa MT, Seth PP, Zanardi TA, Prakash TP, Swayze EE, Henry SP, Wang Y. Shemesh CS, et al. Among authors: zanardi ta. Mol Ther Nucleic Acids. 2016 May 10;5(5):e319. doi: 10.1038/mtna.2016.31. Mol Ther Nucleic Acids. 2016. PMID: 27164023 Free PMC article.

2

Renal uptake and tolerability of a 2'-O-methoxyethyl modified antisense oligonucleotide (ISIS 113715) in monkey.

Henry SP, Johnson M, Zanardi TA, Fey R, Auyeung D, Lappin PB, Levin AA. Henry SP, et al. Among authors: zanardi ta. Toxicology. 2012 Nov 15;301(1-3):13-20. doi: 10.1016/j.tox.2012.06.005. Epub 2012 Jun 16. Toxicology. 2012. PMID: 22709826

3

Pharmacodynamics and subchronic toxicity in mice and monkeys of ISIS 388626, a second-generation antisense oligonucleotide that targets human sodium glucose cotransporter 2.

Zanardi TA, Han SC, Jeong EJ, Rime S, Yu RZ, Chakravarty K, Henry SP. Zanardi TA, et al. J Pharmacol Exp Ther. 2012 Nov;343(2):489-96. doi: 10.1124/jpet.112.197426. Epub 2012 Aug 22. J Pharmacol Exp Ther. 2012. PMID: 22915769

4

Inhibiting C-reactive protein for the treatment of cardiovascular disease: promising evidence from rodent models.

Szalai AJ, McCrory MA, Xing D, Hage FG, Miller A, Oparil S, Chen YF, Mazzone M, Early R, Henry SP, Zanardi TA, Graham MJ, Crooke RM. Szalai AJ, et al. Among authors: zanardi ta. Mediators Inflamm. 2014;2014:353614. doi: 10.1155/2014/353614. Epub 2014 Apr 2. Mediators Inflamm. 2014. PMID: 24803739 Free PMC article.

5

Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice.

Yu RZ, Graham MJ, Post N, Riney S, Zanardi T, Hall S, Burkey J, Shemesh CS, Prakash TP, Seth PP, Swayze EE, Geary RS, Wang Y, Henry S. Yu RZ, et al. Mol Ther Nucleic Acids. 2016 May 3;5(5):e317. doi: 10.1038/mtna.2016.26. Mol Ther Nucleic Acids. 2016. PMID: 27138177 Free PMC article.

6

Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.

Yu RZ, Gunawan R, Post N, Zanardi T, Hall S, Burkey J, Kim TW, Graham MJ, Prakash TP, Seth PP, Swayze EE, Geary RS, Henry SP, Wang Y. Yu RZ, et al. Nucleic Acid Ther. 2016 Dec;26(6):372-380. doi: 10.1089/nat.2016.0623. Epub 2016 Aug 8. Nucleic Acid Ther. 2016. PMID: 27500733

7

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.

DeVos SL, Miller RL, Schoch KM, Holmes BB, Kebodeaux CS, Wegener AJ, Chen G, Shen T, Tran H, Nichols B, Zanardi TA, Kordasiewicz HB, Swayze EE, Bennett CF, Diamond MI, Miller TM. DeVos SL, et al. Among authors: zanardi ta. Sci Transl Med. 2017 Jan 25;9(374):eaag0481. doi: 10.1126/scitranslmed.aag0481. Sci Transl Med. 2017. PMID: 28123067 Free PMC article.

8

Chronic Toxicity Assessment of 2'-O-Methoxyethyl Antisense Oligonucleotides in Mice.

Zanardi TA, Kim TW, Shen L, Serota D, Papagiannis C, Park SY, Kim Y, Henry SP. Zanardi TA, et al. Nucleic Acid Ther. 2018 Aug;28(4):233-241. doi: 10.1089/nat.2017.0706. Epub 2018 Apr 30. Nucleic Acid Ther. 2018. PMID: 29708844

9

Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6.

Zanardi TA, Korbmacher B, Boone L, Engelhardt JA, Wang Y, Burel S, Prill B, Aghajan M, Guo S, Henry SP. Zanardi TA, et al. J Pharmacol Exp Ther. 2021 Apr;377(1):51-63. doi: 10.1124/jpet.120.000222. Epub 2021 Jan 11. J Pharmacol Exp Ther. 2021. PMID: 33431610

10

Complement C3d/C4d Deposition on Platelets Correlates with 2'-O-Methoxyethyl Antisense Oligonucleotide-Induced Thrombocytopenia in Monkeys.

Shen L, Wong A, Oneda S, Curtis BR, Schroeder J, Zanardi T, Engelhardt JA, Henry SP, Narayanan P. Shen L, et al. Nucleic Acid Ther. 2023 Jun;33(3):209-225. doi: 10.1089/nat.2022.0042. Epub 2023 Apr 21. Nucleic Acid Ther. 2023. PMID: 37093125

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