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MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.
O'Brien R, Tran SL, Maritz MF, Liu B, Kong CF, Purgato S, Yang C, Murray J, Russell AJ, Flemming CL, von Jonquieres G, Pickett HA, London WB, Haber M, Gunaratne PH, Norris MD, Perini G, Fletcher JI, MacKenzie KL. O'Brien R, et al. Among authors: mackenzie kl. Cancer Res. 2016 Jun 15;76(12):3604-17. doi: 10.1158/0008-5472.CAN-15-0879. Epub 2016 Apr 13. Cancer Res. 2016. PMID: 27197171
p53 determines multidrug sensitivity of childhood neuroblastoma.
Xue C, Haber M, Flemming C, Marshall GM, Lock RB, MacKenzie KL, Gurova KV, Norris MD, Gudkov AV. Xue C, et al. Among authors: mackenzie kl. Cancer Res. 2007 Nov 1;67(21):10351-60. doi: 10.1158/0008-5472.CAN-06-4345. Cancer Res. 2007. PMID: 17974978
WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.
Sun Y, Bell JL, Carter D, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Hüttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu T. Sun Y, et al. Among authors: mackenzie kl. Cancer Res. 2015 Dec 1;75(23):5143-54. doi: 10.1158/0008-5472.CAN-15-0423. Epub 2015 Oct 15. Cancer Res. 2015. PMID: 26471359
Targeting telomerase in hematologic malignancy.
Maritz MF, Napier CE, Wen VW, MacKenzie KL. Maritz MF, et al. Among authors: mackenzie kl. Future Oncol. 2010 May;6(5):769-89. doi: 10.2217/fon.10.42. Future Oncol. 2010. PMID: 20465390 Review.
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.
Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, Iraci N, Valli E, Ling D, Thomas W, van Bekkum M, Sekyere E, Jankowski K, Trahair T, Mackenzie KL, Haber M, Norris MD, Biankin AV, Perini G, Liu T. Marshall GM, et al. Among authors: mackenzie kl. PLoS Genet. 2011 Jun;7(6):e1002135. doi: 10.1371/journal.pgen.1002135. Epub 2011 Jun 16. PLoS Genet. 2011. PMID: 21698133 Free PMC article.
DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts.
Richards LA, Kumari A, Knezevic K, Thoms JA, von Jonquieres G, Napier CE, Ali Z, O'Brien R, Marks-Bluth J, Maritz MF, Pickett HA, Morris J, Pimanda JE, MacKenzie KL. Richards LA, et al. Among authors: mackenzie kl. Haematologica. 2020 Jun;105(6):1517-1526. doi: 10.3324/haematol.2018.215699. Epub 2019 Aug 14. Haematologica. 2020. PMID: 31413099 Free PMC article.
Telomerase promotes formation of a telomere protective complex in cancer cells.
Perera ON, Sobinoff AP, Teber ET, Harman A, Maritz MF, Yang SF, Pickett HA, Cesare AJ, Arthur JW, MacKenzie KL, Bryan TM. Perera ON, et al. Among authors: mackenzie kl. Sci Adv. 2019 Oct 2;5(10):eaav4409. doi: 10.1126/sciadv.aav4409. eCollection 2019 Oct. Sci Adv. 2019. PMID: 31616780 Free PMC article.
Targeted Therapy of TERT-Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy.
Chen J, Nelson C, Wong M, Tee AE, Liu PY, La T, Fletcher JI, Kamili A, Mayoh C, Bartenhagen C, Trahair TN, Xu N, Jayatilleke N, Wong M, Peng H, Atmadibrata B, Cheung BB, Lan Q, Bryan TM, Mestdagh P, Vandesompele J, Combaret V, Boeva V, Wang JY, Janoueix-Lerosey I, Cowley MJ, MacKenzie KL, Dolnikov A, Li J, Polly P, Marshall GM, Reddel RR, Norris MD, Haber M, Fischer M, Zhang XD, Pickett HA, Liu T. Chen J, et al. Among authors: mackenzie kl. Clin Cancer Res. 2021 Mar 1;27(5):1438-1451. doi: 10.1158/1078-0432.CCR-20-3044. Epub 2020 Dec 11. Clin Cancer Res. 2021. PMID: 33310889
Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress.
Kan CY, Petti C, Bracken L, Maritz M, Xu N, O'Brien R, Yang C, Liu T, Yuan J, Lock RB, MacKenzie KL. Kan CY, et al. Among authors: mackenzie kl. J Biol Chem. 2013 Apr 26;288(17):12032-41. doi: 10.1074/jbc.M112.447821. Epub 2013 Feb 28. J Biol Chem. 2013. PMID: 23449974 Free PMC article.
69 results