Kluck RM - Search Results

1

Physiological restraint of Bak by Bcl-xL is essential for cell survival.

Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD. Lee EF, et al. Among authors: kluck rm. Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19. Genes Dev. 2016. PMID: 27198225 Free PMC article.

2

Mitochondrial release of pro-apoptotic proteins: electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes.

Uren RT, Dewson G, Bonzon C, Lithgow T, Newmeyer DD, Kluck RM. Uren RT, et al. Among authors: kluck rm. J Biol Chem. 2005 Jan 21;280(3):2266-74. doi: 10.1074/jbc.M411106200. Epub 2004 Nov 9. J Biol Chem. 2005. PMID: 15537572 Free article.

3

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC. Willis SN, et al. Among authors: kluck rm. Science. 2007 Feb 9;315(5813):856-9. doi: 10.1126/science.1133289. Science. 2007. PMID: 17289999

4

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM, Kluck RM. Uren RT, et al. Among authors: kluck rm. J Cell Biol. 2007 Apr 23;177(2):277-87. doi: 10.1083/jcb.200606065. J Cell Biol. 2007. PMID: 17452531 Free PMC article.

5

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM. Dewson G, et al. Among authors: kluck rm. Mol Cell. 2008 May 9;30(3):369-80. doi: 10.1016/j.molcel.2008.04.005. Mol Cell. 2008. PMID: 18471982 Free article.

6

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis.

Dewson G, Kluck RM. Dewson G, et al. Among authors: kluck rm. J Cell Sci. 2009 Aug 15;122(Pt 16):2801-8. doi: 10.1242/jcs.038166. J Cell Sci. 2009. PMID: 19795525 Free PMC article.

7

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.

Dewson G, Kratina T, Czabotar P, Day CL, Adams JM, Kluck RM. Dewson G, et al. Among authors: kluck rm. Mol Cell. 2009 Nov 25;36(4):696-703. doi: 10.1016/j.molcel.2009.11.008. Mol Cell. 2009. PMID: 19941828 Free article.

8

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor.

Lazarou M, Stojanovski D, Frazier AE, Kotevski A, Dewson G, Craigen WJ, Kluck RM, Vaux DL, Ryan MT. Lazarou M, et al. Among authors: kluck rm. J Biol Chem. 2010 Nov 19;285(47):36876-83. doi: 10.1074/jbc.M110.159301. Epub 2010 Sep 17. J Biol Chem. 2010. PMID: 20851889 Free PMC article.

9

Molecular biology of Bax and Bak activation and action.

Westphal D, Dewson G, Czabotar PE, Kluck RM. Westphal D, et al. Among authors: kluck rm. Biochim Biophys Acta. 2011 Apr;1813(4):521-31. doi: 10.1016/j.bbamcr.2010.12.019. Epub 2010 Dec 30. Biochim Biophys Acta. 2011. PMID: 21195116 Free article. Review.

10

Bax dimerizes via a symmetric BH3:groove interface during apoptosis.

Dewson G, Ma S, Frederick P, Hockings C, Tan I, Kratina T, Kluck RM. Dewson G, et al. Among authors: kluck rm. Cell Death Differ. 2012 Apr;19(4):661-70. doi: 10.1038/cdd.2011.138. Epub 2011 Oct 21. Cell Death Differ. 2012. PMID: 22015607 Free PMC article.

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