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Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 Gene.
Rodríguez A, Gonzalez L, Ko A, Alvarez M, Miao Z, Bhagat Y, Nikkola E, Cruz-Bautista I, Arellano-Campos O, Muñoz-Hernández LL, Ordóñez-Sánchez ML, Rodriguez-Guillen R, Mohlke KL, Laakso M, Tusie-Luna T, Aguilar-Salinas CA, Pajukanta P. Rodríguez A, et al. Among authors: ko a. Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1350-5. doi: 10.1161/ATVBAHA.116.307182. Epub 2016 May 19. Arterioscler Thromb Vasc Biol. 2016. PMID: 27199446 Free PMC article.
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS.
Pan DZ, Garske KM, Alvarez M, Bhagat YV, Boocock J, Nikkola E, Miao Z, Raulerson CK, Cantor RM, Civelek M, Glastonbury CA, Small KS, Boehnke M, Lusis AJ, Sinsheimer JS, Mohlke KL, Laakso M, Pajukanta P, Ko A. Pan DZ, et al. Among authors: ko a. Nat Commun. 2018 Apr 17;9(1):1512. doi: 10.1038/s41467-018-03554-9. Nat Commun. 2018. PMID: 29666371 Free PMC article.
Integrative approaches for large-scale transcriptome-wide association studies.
Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, Jansen R, de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E, Alvarez M, Civelek M, Lusis AJ, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Raitakari OT, Kuusisto J, Laakso M, Price AL, Pajukanta P, Pasaniuc B. Gusev A, et al. Among authors: ko a. Nat Genet. 2016 Mar;48(3):245-52. doi: 10.1038/ng.3506. Epub 2016 Feb 8. Nat Genet. 2016. PMID: 26854917 Free PMC article.
The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance.
Miao Z, Alvarez M, Ko A, Bhagat Y, Rahmani E, Jew B, Heinonen S, Muñoz-Hernandez LL, Herrera-Hernandez M, Aguilar-Salinas C, Tusie-Luna T, Mohlke KL, Laakso M, Pietiläinen KH, Halperin E, Pajukanta P. Miao Z, et al. Among authors: ko a. PLoS Genet. 2020 Sep 14;16(9):e1009018. doi: 10.1371/journal.pgen.1009018. eCollection 2020 Sep. PLoS Genet. 2020. PMID: 32925908 Free PMC article.
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits.
Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stančáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T, Collins FS, Gargalovic PS, Boehnke M, Laakso M, Mohlke KL, Lusis AJ. Civelek M, et al. Among authors: ko a. Am J Hum Genet. 2017 Mar 2;100(3):428-443. doi: 10.1016/j.ajhg.2017.01.027. Am J Hum Genet. 2017. PMID: 28257690 Free PMC article.
Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family.
Nikkola E, Ko A, Alvarez M, Cantor RM, Garske K, Kim E, Gee S, Rodriguez A, Muxel R, Matikainen N, Söderlund S, Motazacker MM, Borén J, Lamina C, Kronenberg F, Schneider WJ, Palotie A, Laakso M, Taskinen MR, Pajukanta P. Nikkola E, et al. Among authors: ko a. Atherosclerosis. 2017 Sep;264:58-66. doi: 10.1016/j.atherosclerosis.2017.07.024. Epub 2017 Jul 22. Atherosclerosis. 2017. PMID: 28772107 Free PMC article.
ASElux: an ultra-fast and accurate allelic reads counter.
Miao Z, Alvarez M, Pajukanta P, Ko A. Miao Z, et al. Among authors: ko a. Bioinformatics. 2018 Apr 15;34(8):1313-1320. doi: 10.1093/bioinformatics/btx762. Bioinformatics. 2018. PMID: 29186329 Free PMC article.
Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits.
Raulerson CK, Ko A, Kidd JC, Currin KW, Brotman SM, Cannon ME, Wu Y, Spracklen CN, Jackson AU, Stringham HM, Welch RP, Fuchsberger C, Locke AE, Narisu N, Lusis AJ, Civelek M, Furey TS, Kuusisto J, Collins FS, Boehnke M, Scott LJ, Lin DY, Love MI, Laakso M, Pajukanta P, Mohlke KL. Raulerson CK, et al. Among authors: ko a. Am J Hum Genet. 2019 Oct 3;105(4):773-787. doi: 10.1016/j.ajhg.2019.09.001. Epub 2019 Sep 26. Am J Hum Genet. 2019. PMID: 31564431 Free PMC article.
Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution.
Wu Y, Broadaway KA, Raulerson CK, Scott LJ, Pan C, Ko A, He A, Tilford C, Fuchsberger C, Locke AE, Stringham HM, Jackson AU, Narisu N, Kuusisto J, Pajukanta P, Collins FS, Boehnke M, Laakso M, Lusis AJ, Civelek M, Mohlke KL. Wu Y, et al. Among authors: ko a. Hum Mol Genet. 2019 Dec 15;28(24):4161-4172. doi: 10.1093/hmg/ddz263. Hum Mol Genet. 2019. PMID: 31691812 Free PMC article.
Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.
Pan DZ, Miao Z, Comenho C, Rajkumar S, Koka A, Lee SHT, Alvarez M, Kaminska D, Ko A, Sinsheimer JS, Mohlke KL, Mancuso N, Muñoz-Hernandez LL, Herrera-Hernandez M, Tusié-Luna MT, Aguilar-Salinas C, Pietiläinen KH, Pihlajamäki J, Laakso M, Garske KM, Pajukanta P. Pan DZ, et al. Among authors: ko a. Genome Med. 2021 Aug 2;13(1):123. doi: 10.1186/s13073-021-00939-2. Genome Med. 2021. PMID: 34340684 Free PMC article.
1,287 results