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A phase I dose escalation trial of AXP107-11, a novel multi-component crystalline form of genistein, in combination with gemcitabine in chemotherapy-naive patients with unresectable pancreatic cancer.
Löhr JM, Karimi M, Omazic B, Kartalis N, Verbeke CS, Berkenstam A, Frödin JE. Löhr JM, et al. Among authors: berkenstam a. Pancreatology. 2016 Jul-Aug;16(4):640-5. doi: 10.1016/j.pan.2016.05.002. Epub 2016 May 14. Pancreatology. 2016. PMID: 27234064 Clinical Trial.
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling.
Mesmar F, Dai B, Ibrahim A, Hases L, Jafferali MH, Jose Augustine J, DiLorenzo S, Kang Y, Zhao Y, Wang J, Kim M, Lin CY, Berkenstam A, Fleming J, Williams C. Mesmar F, et al. Among authors: berkenstam a. Cancer Med. 2019 Dec;8(18):7705-7719. doi: 10.1002/cam4.2581. Epub 2019 Sep 30. Cancer Med. 2019. PMID: 31568691 Free PMC article.
The estrogen receptor gene: promoter organization and expression.
Grandien K, Berkenstam A, Gustafsson JA. Grandien K, et al. Among authors: berkenstam a. Int J Biochem Cell Biol. 1997 Dec;29(12):1343-69. doi: 10.1016/s1357-2725(97)89967-0. Int J Biochem Cell Biol. 1997. PMID: 9570132 Review.
A screening cascade to identify ERβ ligands.
Filgueira CS, Benod C, Lou X, Gunamalai PS, Villagomez RA, Strom A, Gustafsson JÅ, Berkenstam AL, Webb P. Filgueira CS, et al. Among authors: berkenstam al. Nucl Recept Signal. 2014 Nov 4;12:e003. doi: 10.1621/nrs.12003. eCollection 2014. Nucl Recept Signal. 2014. PMID: 25422593 Free PMC article.
33 results