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rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits.
Rosner A, Steiner M, Melamed S, Politi B, Vitner E, Tamir H, Achdout H, Cherry L, Avraham R, Yahalom-Ronen Y, Levy H, Beth-Din A, Stein D, Mechaly A, Fisher M, Fatelevich E, Weiss S, Kronfeld N, Madar-Shapiro L, Nyska A, Yitzhaki S, Paran N, Israely T, Marcus H, Madar-Balakirski N. Rosner A, et al. Among authors: yitzhaki s. Arch Toxicol. 2022 Aug;96(8):2329-2339. doi: 10.1007/s00204-022-03302-5. Epub 2022 May 17. Arch Toxicol. 2022. PMID: 35577986 Free PMC article.
A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes.
Noy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R. Noy-Porat T, et al. Among authors: yitzhaki s. Nat Commun. 2020 Aug 27;11(1):4303. doi: 10.1038/s41467-020-18159-4. Nat Commun. 2020. PMID: 32855401 Free PMC article.
Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody.
Rosenfeld R, Noy-Porat T, Mechaly A, Makdasi E, Levy Y, Alcalay R, Falach R, Aftalion M, Epstein E, Gur D, Chitlaru T, Vitner EB, Melamed S, Politi B, Zauberman A, Lazar S, Beth-Din A, Evgy Y, Yitzhaki S, Shapira SC, Israely T, Mazor O. Rosenfeld R, et al. Among authors: yitzhaki s. Nat Commun. 2021 Feb 11;12(1):944. doi: 10.1038/s41467-021-21239-8. Nat Commun. 2021. PMID: 33574228 Free PMC article.
Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice.
Noy-Porat T, Mechaly A, Levy Y, Makdasi E, Alcalay R, Gur D, Aftalion M, Falach R, Leviatan Ben-Arye S, Lazar S, Zauberman A, Epstein E, Chitlaru T, Weiss S, Achdout H, Edgeworth JD, Kikkeri R, Yu H, Chen X, Yitzhaki S, Shapira SC, Padler-Karavani V, Mazor O, Rosenfeld R. Noy-Porat T, et al. Among authors: yitzhaki s. iScience. 2021 May 21;24(5):102479. doi: 10.1016/j.isci.2021.102479. Epub 2021 Apr 26. iScience. 2021. PMID: 33937725 Free PMC article.
The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against viral variants.
Makdasi E, Zvi A, Alcalay R, Noy-Porat T, Peretz E, Mechaly A, Levy Y, Epstein E, Chitlaru T, Tennenhouse A, Aftalion M, Gur D, Paran N, Tamir H, Zimhony O, Weiss S, Mandelboim M, Mendelson E, Zuckerman N, Nemet I, Kliker L, Yitzhaki S, Shapira SC, Israely T, Fleishman SJ, Mazor O, Rosenfeld R. Makdasi E, et al. Among authors: yitzhaki s. Cell Rep. 2021 Sep 7;36(10):109679. doi: 10.1016/j.celrep.2021.109679. Epub 2021 Aug 21. Cell Rep. 2021. PMID: 34464610 Free PMC article.
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