Jude K - Search Results

1

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer.

Weiskopf K, Jahchan NS, Schnorr PJ, Cristea S, Ring AM, Maute RL, Volkmer AK, Volkmer JP, Liu J, Lim JS, Yang D, Seitz G, Nguyen T, Wu D, Jude K, Guerston H, Barkal A, Trapani F, George J, Poirier JT, Gardner EE, Miles LA, de Stanchina E, Lofgren SM, Vogel H, Winslow MM, Dive C, Thomas RK, Rudin CM, van de Rijn M, Majeti R, Garcia KC, Weissman IL, Sage J. Weiskopf K, et al. Among authors: jude k. J Clin Invest. 2016 Jul 1;126(7):2610-20. doi: 10.1172/JCI81603. Epub 2016 Jun 13. J Clin Invest. 2016. PMID: 27294525 Free PMC article.

2

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.

Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC. Spangler JB, et al. Among authors: jude km. Immunity. 2015 May 19;42(5):815-25. doi: 10.1016/j.immuni.2015.04.015. Immunity. 2015. PMID: 25992858 Free PMC article.

3

Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch.

De Paula VS, Jude KM, Nerli S, Glassman CR, Garcia KC, Sgourakis NG. De Paula VS, et al. Among authors: jude km. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7183-7192. doi: 10.1073/pnas.2000419117. Epub 2020 Mar 17. Proc Natl Acad Sci U S A. 2020. PMID: 32184322 Free PMC article.

4

Structural biology. Structural basis for Notch1 engagement of Delta-like 4.

Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC. Luca VC, et al. Among authors: jude km. Science. 2015 Feb 20;347(6224):847-53. doi: 10.1126/science.1261093. Science. 2015. PMID: 25700513 Free PMC article.

5

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.

Moraga I, Richter D, Wilmes S, Winkelmann H, Jude K, Thomas C, Suhoski MM, Engleman EG, Piehler J, Garcia KC. Moraga I, et al. Among authors: jude k. Sci Signal. 2015 Nov 10;8(402):ra114. doi: 10.1126/scisignal.aab2677. Sci Signal. 2015. PMID: 26554818 Free PMC article.

6

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.

Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC. Sockolosky JT, et al. Among authors: jude k. Science. 2018 Mar 2;359(6379):1037-1042. doi: 10.1126/science.aar3246. Science. 2018. PMID: 29496879 Free PMC article.

7

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.

Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA. Trotta E, et al. Among authors: jude km. Nat Med. 2018 Jul;24(7):1005-1014. doi: 10.1038/s41591-018-0070-2. Epub 2018 Jun 25. Nat Med. 2018. PMID: 29942088 Free PMC article.

8

Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro.

Gee MH, Sibener LV, Birnbaum ME, Jude KM, Yang X, Fernandes RA, Mendoza JL, Glassman CR, Garcia KC. Gee MH, et al. Among authors: jude km. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7369-E7378. doi: 10.1073/pnas.1802746115. Epub 2018 Jul 18. Proc Natl Acad Sci U S A. 2018. PMID: 30021852 Free PMC article.

9

Structure of the IFNγ receptor complex guides design of biased agonists.

Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC. Mendoza JL, et al. Among authors: jude km. Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27. Nature. 2019. PMID: 30814731 Free PMC article.

10

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.

Mohan K, Ueda G, Kim AR, Jude KM, Fallas JA, Guo Y, Hafer M, Miao Y, Saxton RA, Piehler J, Sankaran VG, Baker D, Garcia KC. Mohan K, et al. Among authors: jude km. Science. 2019 May 24;364(6442):eaav7532. doi: 10.1126/science.aav7532. Epub 2019 May 23. Science. 2019. PMID: 31123111 Free PMC article.

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