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Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.
Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB. Giles K, et al. Among authors: silber bm. J Pharmacol Exp Ther. 2016 Sep;358(3):537-47. doi: 10.1124/jpet.116.235556. Epub 2016 Jun 17. J Pharmacol Exp Ther. 2016. PMID: 27317802 Free PMC article.
Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.
Lu D, Giles K, Li Z, Rao S, Dolghih E, Gever JR, Geva M, Elepano ML, Oehler A, Bryant C, Renslo AR, Jacobson MP, Dearmond SJ, Silber BM, Prusiner SB. Lu D, et al. Among authors: silber bm. J Pharmacol Exp Ther. 2013 Nov;347(2):325-38. doi: 10.1124/jpet.113.205799. Epub 2013 Aug 21. J Pharmacol Exp Ther. 2013. PMID: 23965382 Free PMC article.
Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.
Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. Giles K, et al. Among authors: silber bm. J Pharmacol Exp Ther. 2015 Oct;355(1):2-12. doi: 10.1124/jpet.115.224659. Epub 2015 Jul 29. J Pharmacol Exp Ther. 2015. PMID: 26224882 Free PMC article.
2-Aminothiazoles as therapeutic leads for prion diseases.
Gallardo-Godoy A, Gever J, Fife KL, Silber BM, Prusiner SB, Renslo AR. Gallardo-Godoy A, et al. Among authors: silber bm. J Med Chem. 2011 Feb 24;54(4):1010-21. doi: 10.1021/jm101250y. Epub 2011 Jan 19. J Med Chem. 2011. PMID: 21247166 Free PMC article.
Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.
Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Silber BM, et al. Pharm Res. 2013 Apr;30(4):932-50. doi: 10.1007/s11095-012-0912-4. Epub 2013 Feb 16. Pharm Res. 2013. PMID: 23417511 Free PMC article.
47 results