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Cdk2 catalytic activity is essential for meiotic cell division in vivo.
Chauhan S, Diril MK, Lee JH, Bisteau X, Manoharan V, Adhikari D, Ratnacaram CK, Janela B, Noffke J, Ginhoux F, Coppola V, Liu K, Tessarollo L, Kaldis P. Chauhan S, et al. Among authors: coppola v. Biochem J. 2016 Sep 15;473(18):2783-98. doi: 10.1042/BCJ20160607. Epub 2016 Jul 1. Biochem J. 2016. PMID: 27371320 Free PMC article.
Cdk2 knockout mice are viable.
Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P. Berthet C, et al. Among authors: coppola v. Curr Biol. 2003 Oct 14;13(20):1775-85. doi: 10.1016/j.cub.2003.09.024. Curr Biol. 2003. PMID: 14561402 Free article.
Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis.
Gopinathan L, Tan SL, Padmakumar VC, Coppola V, Tessarollo L, Kaldis P. Gopinathan L, et al. Among authors: coppola v. Cancer Res. 2014 Jul 15;74(14):3870-9. doi: 10.1158/0008-5472.CAN-13-3440. Epub 2014 May 6. Cancer Res. 2014. PMID: 24802190 Free PMC article.
Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation.
Tu Z, Bayazit MB, Liu H, Zhang J, Busayavalasa K, Risal S, Shao J, Satyanarayana A, Coppola V, Tessarollo L, Singh M, Zheng C, Han C, Chen Z, Kaldis P, Gustafsson JÅ, Liu K. Tu Z, et al. Among authors: coppola v. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):592-597. doi: 10.1073/pnas.1618465114. Epub 2016 Dec 28. Proc Natl Acad Sci U S A. 2017. PMID: 28031483 Free PMC article.
Emi2 Is Essential for Mouse Spermatogenesis.
Gopinathan L, Szmyd R, Low D, Diril MK, Chang HY, Coppola V, Liu K, Tessarollo L, Guccione E, van Pelt AMM, Kaldis P. Gopinathan L, et al. Among authors: coppola v. Cell Rep. 2017 Jul 18;20(3):697-708. doi: 10.1016/j.celrep.2017.06.033. Cell Rep. 2017. PMID: 28723571 Free PMC article.
CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.
Windpassinger C, Piard J, Bonnard C, Alfadhel M, Lim S, Bisteau X, Blouin S, Ali NB, Ng AYJ, Lu H, Tohari S, Talib SZA, van Hul N, Caldez MJ, Van Maldergem L, Yigit G, Kayserili H, Youssef SA, Coppola V, de Bruin A, Tessarollo L, Choi H, Rupp V, Roetzer K, Roschger P, Klaushofer K, Altmüller J, Roy S, Venkatesh B, Ganger R, Grill F, Ben Chehida F, Wollnik B, Altunoglu U, Al Kaissi A, Reversade B, Kaldis P. Windpassinger C, et al. Among authors: coppola v. Am J Hum Genet. 2017 Sep 7;101(3):391-403. doi: 10.1016/j.ajhg.2017.08.003. Am J Hum Genet. 2017. PMID: 28886341 Free PMC article.
250 results