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Page 1
Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.
Quek L, Otto GW, Garnett C, Lhermitte L, Karamitros D, Stoilova B, Lau IJ, Doondeea J, Usukhbayar B, Kennedy A, Metzner M, Goardon N, Ivey A, Allen C, Gale R, Davies B, Sternberg A, Killick S, Hunter H, Cahalin P, Price A, Carr A, Griffiths M, Virgo P, Mackinnon S, Grimwade D, Freeman S, Russell N, Craddock C, Mead A, Peniket A, Porcher C, Vyas P. Quek L, et al. Among authors: doondeea j. J Exp Med. 2016 Jul 25;213(8):1513-35. doi: 10.1084/jem.20151775. Epub 2016 Jul 4. J Exp Med. 2016. PMID: 27377587 Free PMC article. Clinical Trial.
Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.
Karamitros D, Stoilova B, Aboukhalil Z, Hamey F, Reinisch A, Samitsch M, Quek L, Otto G, Repapi E, Doondeea J, Usukhbayar B, Calvo J, Taylor S, Goardon N, Six E, Pflumio F, Porcher C, Majeti R, Göttgens B, Vyas P. Karamitros D, et al. Among authors: doondeea j. Nat Immunol. 2018 Jan;19(1):85-97. doi: 10.1038/s41590-017-0001-2. Epub 2017 Nov 21. Nat Immunol. 2018. PMID: 29167569 Free PMC article.
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR. Mettananda S, et al. Among authors: doondeea j. Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7. Nat Commun. 2017. PMID: 28871148 Free PMC article.
Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay.
Juban G, Sakakini N, Chagraoui H, Cruz Hernandez D, Cheng Q, Soady K, Stoilova B, Garnett C, Waithe D, Otto G, Doondeea J, Usukhbayar B, Karkoulia E, Alexiou M, Strouboulis J, Morrissey E, Roberts I, Porcher C, Vyas P. Juban G, et al. Among authors: doondeea j. Haematologica. 2021 Apr 1;106(4):1106-1119. doi: 10.3324/haematol.2019.244541. Haematologica. 2021. PMID: 32527952 Free PMC article.
ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63.
Tordella L, Koch S, Salter V, Pagotto A, Doondeea JB, Feller SM, Ratnayaka I, Zhong S, Goldin RD, Lozano G, McKeon FD, Tavassoli M, Fritzsche F, Huber GF, Rössle M, Moch H, Lu X. Tordella L, et al. Among authors: doondeea jb. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17969-74. doi: 10.1073/pnas.1309362110. Epub 2013 Oct 14. Proc Natl Acad Sci U S A. 2013. PMID: 24127607 Free PMC article.
YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets.
Ehsanian R, Brown M, Lu H, Yang XP, Pattatheyil A, Yan B, Duggal P, Chuang R, Doondeea J, Feller S, Sudol M, Chen Z, Van Waes C. Ehsanian R, et al. Among authors: doondeea j. Oncogene. 2010 Nov 18;29(46):6160-71. doi: 10.1038/onc.2010.339. Epub 2010 Aug 23. Oncogene. 2010. PMID: 20729916 Free PMC article.