Garzan A - Search Results

1

Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors.

LaPorte MG, Wang Z, Colombo R, Garzan A, Peshkov VA, Liang M, Johnston PA, Schurdak ME, Sen M, Camarco DP, Hua Y, Pollock NI, Lazo JS, Grandis JR, Wipf P, Huryn DM. LaPorte MG, et al. Among authors: garzan a. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3581-5. doi: 10.1016/j.bmcl.2016.06.017. Epub 2016 Jun 9. Bioorg Med Chem Lett. 2016. PMID: 27381083 Free PMC article.

2

Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.

Garzan A, Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV, Posey JE, Garneau-Tsodikova S. Garzan A, et al. J Med Chem. 2016 Dec 8;59(23):10619-10628. doi: 10.1021/acs.jmedchem.6b01161. Epub 2016 Nov 22. J Med Chem. 2016. PMID: 27933949 Free PMC article.

3

Repurposing antipsychotic drugs into antifungal agents: Synergistic combinations of azoles and bromperidol derivatives in the treatment of various fungal infections.

Holbrook SYL, Garzan A, Dennis EK, Shrestha SK, Garneau-Tsodikova S. Holbrook SYL, et al. Among authors: garzan a. Eur J Med Chem. 2017 Oct 20;139:12-21. doi: 10.1016/j.ejmech.2017.07.030. Epub 2017 Jul 19. Eur J Med Chem. 2017. PMID: 28797882

4

Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis.

Garzan A, Willby MJ, Green KD, Tsodikov OV, Posey JE, Garneau-Tsodikova S. Garzan A, et al. ACS Med Chem Lett. 2016 Sep 15;7(12):1219-1221. doi: 10.1021/acsmedchemlett.6b00261. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994767 Free PMC article.

5

Novel alkylated azoles as potent antifungals.

Shrestha SK, Garzan A, Garneau-Tsodikova S. Shrestha SK, et al. Among authors: garzan a. Eur J Med Chem. 2017 Jun 16;133:309-318. doi: 10.1016/j.ejmech.2017.03.075. Epub 2017 Mar 31. Eur J Med Chem. 2017. PMID: 28395217

6

Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity.

Pang AH, Green KD, Chandrika NT, Garzan A, Punetha A, Holbrook SYL, Willby MJ, Posey JE, Tsodikov OV, Garneau-Tsodikova S. Pang AH, et al. Among authors: garzan a. Eur J Med Chem. 2022 Nov 15;242:114698. doi: 10.1016/j.ejmech.2022.114698. Epub 2022 Aug 18. Eur J Med Chem. 2022. PMID: 36037791 Free PMC article.

7

Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors.

Garzan A, Willby MJ, Ngo HX, Gajadeera CS, Green KD, Holbrook SY, Hou C, Posey JE, Tsodikov OV, Garneau-Tsodikova S. Garzan A, et al. ACS Infect Dis. 2017 Apr 14;3(4):302-309. doi: 10.1021/acsinfecdis.6b00193. Epub 2017 Feb 17. ACS Infect Dis. 2017. PMID: 28192916 Free PMC article.

8

Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.

Ngo HX, Green KD, Gajadeera CS, Willby MJ, Holbrook SYL, Hou C, Garzan A, Mayhoub AS, Posey JE, Tsodikov OV, Garneau-Tsodikova S. Ngo HX, et al. Among authors: garzan a. ACS Infect Dis. 2018 Jun 8;4(6):1030-1040. doi: 10.1021/acsinfecdis.8b00074. Epub 2018 Mar 30. ACS Infect Dis. 2018. PMID: 29601176 Free PMC article.

9

Discovery and Optimization of 6-(1-Substituted pyrrole-2-yl)-s-triazine Containing Compounds as Antibacterial Agents.

Green KD, Pang AH, Thamban Chandrika N, Garzan A, Baughn AD, Tsodikov OV, Garneau-Tsodikova S. Green KD, et al. Among authors: garzan a. ACS Infect Dis. 2022 Apr 8;8(4):757-767. doi: 10.1021/acsinfecdis.1c00450. Epub 2022 Mar 3. ACS Infect Dis. 2022. PMID: 35239306

10

Deciphering Nature's Intricate Way of N,S-Dimethylating l-Cysteine: Sequential Action of Two Bifunctional Adenylation Domains.

Mori S, Garzan A, Tsodikov OV, Garneau-Tsodikova S. Mori S, et al. Among authors: garzan a. Biochemistry. 2017 Nov 21;56(46):6087-6097. doi: 10.1021/acs.biochem.7b00980. Epub 2017 Nov 7. Biochemistry. 2017. PMID: 29112395

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