Holland ML - Search Results

1

Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice.

Holland ML, Lowe R, Caton PW, Gemma C, Carbajosa G, Danson AF, Carpenter AA, Loche E, Ozanne SE, Rakyan VK. Holland ML, et al. Science. 2016 Jul 29;353(6298):495-8. doi: 10.1126/science.aaf7040. Epub 2016 Jul 7. Science. 2016. PMID: 27386920 Free PMC article.

2

The hunt for the epiallele.

Finer S, Holland ML, Nanty L, Rakyan VK. Finer S, et al. Among authors: holland ml. Environ Mol Mutagen. 2011 Jan;52(1):1-11. doi: 10.1002/em.20590. Environ Mol Mutagen. 2011. PMID: 20839222 Review.

3

Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes.

Proudhon C, Duffié R, Ajjan S, Cowley M, Iranzo J, Carbajosa G, Saadeh H, Holland ML, Oakey RJ, Rakyan VK, Schulz R, Bourc'his D. Proudhon C, et al. Among authors: holland ml. Mol Cell. 2012 Sep 28;47(6):909-20. doi: 10.1016/j.molcel.2012.07.010. Epub 2012 Aug 16. Mol Cell. 2012. PMID: 22902559 Free PMC article.

4

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans.

Beyan H, Down TA, Ramagopalan SV, Uvebrant K, Nilsson A, Holland ML, Gemma C, Giovannoni G, Boehm BO, Ebers GC, Lernmark Å, Cilio CM, Leslie RD, Rakyan VK. Beyan H, et al. Among authors: holland ml. Genome Res. 2012 Nov;22(11):2138-45. doi: 10.1101/gr.134304.111. Epub 2012 Aug 23. Genome Res. 2012. PMID: 22919074 Free PMC article.

5

Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients.

Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC. Caton PW, et al. Among authors: holland ml. Diabetologia. 2013 May;56(5):1068-77. doi: 10.1007/s00125-013-2851-y. Epub 2013 Feb 9. Diabetologia. 2013. PMID: 23397292 Free article.

6

Transgenerational inheritance of non-genetically determined phenotypes.

Holland ML, Rakyan VK. Holland ML, et al. Biochem Soc Trans. 2013 Jun;41(3):769-76. doi: 10.1042/BST20130043. Biochem Soc Trans. 2013. PMID: 23697936 Review.

7

Inactive or moderately active human promoters are enriched for inter-individual epialleles.

Gemma C, Ramagopalan SV, Down TA, Beyan H, Hawa MI, Holland ML, Hurd PJ, Giovannoni G, Leslie RD, Ebers GC, Rakyan VK. Gemma C, et al. Among authors: holland ml. Genome Biol. 2013 May 25;14(5):R43. doi: 10.1186/gb-2013-14-5-r43. Genome Biol. 2013. PMID: 23706135 Free PMC article.

8

Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development.

Lowe R, Gemma C, Rakyan VK, Holland ML. Lowe R, et al. Among authors: holland ml. BMC Genomics. 2015 Apr 14;16(1):295. doi: 10.1186/s12864-015-1506-4. BMC Genomics. 2015. PMID: 25888192 Free PMC article.

9

Early life diet conditions the molecular response to post-weaning protein restriction in the mouse.

Danson AF, Marzi SJ, Lowe R, Holland ML, Rakyan VK. Danson AF, et al. Among authors: holland ml. BMC Biol. 2018 May 2;16(1):51. doi: 10.1186/s12915-018-0516-5. BMC Biol. 2018. PMID: 29720174 Free PMC article.

10

The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations.

Åsenius F, Gorrie-Stone TJ, Brew A, Panchbhaya Y, Williamson E, Schalkwyk LC, Rakyan VK, Holland ML, Marzi SJ, Williams DJ. Åsenius F, et al. Among authors: holland ml. PLoS Genet. 2020 Oct 13;16(10):e1009035. doi: 10.1371/journal.pgen.1009035. eCollection 2020 Oct. PLoS Genet. 2020. PMID: 33048947 Free PMC article.

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