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Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL.
De Leo MG, Staiano L, Vicinanza M, Luciani A, Carissimo A, Mutarelli M, Di Campli A, Polishchuk E, Di Tullio G, Morra V, Levtchenko E, Oltrabella F, Starborg T, Santoro M, Di Bernardo D, Devuyst O, Lowe M, Medina DL, Ballabio A, De Matteis MA. De Leo MG, et al. Among authors: lowe m. Nat Cell Biol. 2016 Aug;18(8):839-850. doi: 10.1038/ncb3386. Epub 2016 Jul 11. Nat Cell Biol. 2016. PMID: 27398910 Free PMC article.
Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network.
Choudhury R, Diao A, Zhang F, Eisenberg E, Saint-Pol A, Williams C, Konstantakopoulos A, Lucocq J, Johannes L, Rabouille C, Greene LE, Lowe M. Choudhury R, et al. Among authors: lowe m. Mol Biol Cell. 2005 Aug;16(8):3467-79. doi: 10.1091/mbc.e05-02-0120. Epub 2005 May 25. Mol Biol Cell. 2005. PMID: 15917292 Free PMC article.
Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction.
Elmonem MA, Khalil R, Khodaparast L, Khodaparast L, Arcolino FO, Morgan J, Pastore A, Tylzanowski P, Ny A, Lowe M, de Witte PA, Baelde HJ, van den Heuvel LP, Levtchenko E. Elmonem MA, et al. Among authors: lowe m. Sci Rep. 2017 Feb 15;7:42583. doi: 10.1038/srep42583. Sci Rep. 2017. PMID: 28198397 Free PMC article.
Genetic Renal Diseases: The Emerging Role of Zebrafish Models.
Elmonem MA, Berlingerio SP, van den Heuvel LP, de Witte PA, Lowe M, Levtchenko EN. Elmonem MA, et al. Among authors: lowe m. Cells. 2018 Sep 1;7(9):130. doi: 10.3390/cells7090130. Cells. 2018. PMID: 30200518 Free PMC article. Review.
Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis.
De Leo E, Elmonem MA, Berlingerio SP, Berquez M, Festa BP, Raso R, Bellomo F, Starborg T, Janssen MJ, Abbaszadeh Z, Cairoli S, Goffredo BM, Masereeuw R, Devuyst O, Lowe M, Levtchenko E, Luciani A, Emma F, Rega LR. De Leo E, et al. Among authors: lowe m. J Am Soc Nephrol. 2020 Jul;31(7):1522-1537. doi: 10.1681/ASN.2019090956. Epub 2020 Jun 5. J Am Soc Nephrol. 2020. PMID: 32503896 Free PMC article.
1,553 results