Grembecka J - Search Results

1

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.

Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH. Illendula A, et al. Among authors: grembecka j. EBioMedicine. 2016 Jun;8:117-131. doi: 10.1016/j.ebiom.2016.04.032. Epub 2016 Apr 29. EBioMedicine. 2016. PMID: 27428424 Free PMC article.

2

MRG15 activates histone methyltransferase activity of ASH1L by recruiting it to the nucleosomes.

Al-Harthi S, Li H, Winkler A, Szczepski K, Deng J, Grembecka J, Cierpicki T, Jaremko Ł. Al-Harthi S, et al. Among authors: grembecka j. Structure. 2023 Oct 5;31(10):1200-1207.e5. doi: 10.1016/j.str.2023.07.001. Epub 2023 Jul 31. Structure. 2023. PMID: 37527654 Free article.

3

High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.

Lukasik SM, Cierpicki T, Borloz M, Grembecka J, Everett A, Bushweller JH. Lukasik SM, et al. Among authors: grembecka j. Protein Sci. 2006 Feb;15(2):314-23. doi: 10.1110/ps.051751706. Epub 2005 Dec 29. Protein Sci. 2006. PMID: 16384999 Free PMC article.

4

The binding of the PDZ tandem of syntenin to target proteins.

Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang BS, Bushweller JH, Derewenda ZS. Grembecka J, et al. Biochemistry. 2006 Mar 21;45(11):3674-83. doi: 10.1021/bi052225y. Biochemistry. 2006. PMID: 16533050

5

A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.

Li Z, Lukasik SM, Liu Y, Grembecka J, Bielnicka I, Bushweller JH, Speck NA. Li Z, et al. Among authors: grembecka j. J Mol Biol. 2006 Dec 15;364(5):1073-83. doi: 10.1016/j.jmb.2006.10.002. Epub 2006 Oct 4. J Mol Biol. 2006. PMID: 17059830 Free PMC article.

6

Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta.

Gorczynski MJ, Grembecka J, Zhou Y, Kong Y, Roudaia L, Douvas MG, Newman M, Bielnicka I, Baber G, Corpora T, Shi J, Sridharan M, Lilien R, Donald BR, Speck NA, Brown ML, Bushweller JH. Gorczynski MJ, et al. Among authors: grembecka j. Chem Biol. 2007 Oct;14(10):1186-97. doi: 10.1016/j.chembiol.2007.09.006. Chem Biol. 2007. PMID: 17961830

7

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

Erfurth FE, Popovic R, Grembecka J, Cierpicki T, Theisler C, Xia ZB, Stuart T, Diaz MO, Bushweller JH, Zeleznik-Le NJ. Erfurth FE, et al. Among authors: grembecka j. Proc Natl Acad Sci U S A. 2008 May 27;105(21):7517-22. doi: 10.1073/pnas.0800090105. Epub 2008 May 15. Proc Natl Acad Sci U S A. 2008. PMID: 18483194 Free PMC article.

8

Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

Cierpicki T, Risner LE, Grembecka J, Lukasik SM, Popovic R, Omonkowska M, Shultis DD, Zeleznik-Le NJ, Bushweller JH. Cierpicki T, et al. Among authors: grembecka j. Nat Struct Mol Biol. 2010 Jan;17(1):62-8. doi: 10.1038/nsmb.1714. Epub 2009 Dec 13. Nat Struct Mol Biol. 2010. PMID: 20010842 Free PMC article.

9

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Shi A, Murai MJ, He S, Lund G, Hartley T, Purohit T, Reddy G, Chruszcz M, Grembecka J, Cierpicki T. Shi A, et al. Among authors: grembecka j. Blood. 2012 Nov 29;120(23):4461-9. doi: 10.1182/blood-2012-05-429274. Epub 2012 Aug 30. Blood. 2012. PMID: 22936661 Free PMC article.

10

Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?

Cierpicki T, Grembecka J. Cierpicki T, et al. Among authors: grembecka j. Immunol Rev. 2015 Jan;263(1):279-301. doi: 10.1111/imr.12244. Immunol Rev. 2015. PMID: 25510283 Free PMC article. Review.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

87 results

Search Page

Filters