Chang SY - Search Results

1

Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function.

Chang SY, Weber EJ, Ness KV, Eaton DL, Kelly EJ. Chang SY, et al. Clin Pharmacol Ther. 2016 Nov;100(5):464-478. doi: 10.1002/cpt.436. Epub 2016 Aug 27. Clin Pharmacol Ther. 2016. PMID: 27448090 Free PMC article. Review.

2

Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity.

Chang SY, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL. Chang SY, et al. Toxicol In Vitro. 2017 Apr;40:170-183. doi: 10.1016/j.tiv.2017.01.007. Epub 2017 Jan 13. Toxicol In Vitro. 2017. PMID: 28089783

3

Microphysiological Systems to Assess Nonclinical Toxicity.

Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Van Ness KP, et al. Among authors: chang sy. Curr Protoc Toxicol. 2017 Aug 4;73:14.18.1-14.18.28. doi: 10.1002/cptx.27. Curr Protoc Toxicol. 2017. PMID: 28777442 Free PMC article.

4

Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity.

Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL. Chang SY, et al. JCI Insight. 2017 Nov 16;2(22):e95978. doi: 10.1172/jci.insight.95978. eCollection 2017 Nov 16. JCI Insight. 2017. PMID: 29202460 Free PMC article.

5

An Improved Vascularized, Dual-Channel Microphysiological System Facilitates Modeling of Proximal Tubular Solute Secretion.

Chapron A, Chapron BD, Hailey DW, Chang SY, Imaoka T, Thummel KE, Kelly E, Himmelfarb J, Shen D, Yeung CK. Chapron A, et al. Among authors: chang sy. ACS Pharmacol Transl Sci. 2020 Jan 28;3(3):496-508. doi: 10.1021/acsptsci.9b00078. eCollection 2020 Jun 12. ACS Pharmacol Transl Sci. 2020. PMID: 32566915 Free PMC article.

6

Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system.

Imaoka T, Huang W, Shum S, Hailey DW, Chang SY, Chapron A, Yeung CK, Himmelfarb J, Isoherranen N, Kelly EJ. Imaoka T, et al. Among authors: chang sy. Sci Rep. 2021 Nov 1;11(1):21356. doi: 10.1038/s41598-021-00338-y. Sci Rep. 2021. PMID: 34725352 Free PMC article.

7

Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease.

Chang SY, Huang W, Chapron A, Quiñones AJL, Wang J, Isoherranen N, Shen DD, Kelly EJ, Himmelfarb J, Yeung CK. Chang SY, et al. Pharm Res. 2023 Nov;40(11):2597-2606. doi: 10.1007/s11095-023-03594-x. Epub 2023 Sep 13. Pharm Res. 2023. PMID: 37704895

8

Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants.

Zou J, Pan YW, Wang Z, Chang SY, Wang W, Wang X, Tournier C, Storm DR, Xia Z. Zou J, et al. Among authors: chang sy. J Neurosci. 2012 Mar 21;32(12):4118-32. doi: 10.1523/JNEUROSCI.6260-11.2012. J Neurosci. 2012. PMID: 22442076 Free PMC article.

9

Prior influenza virus infection alleviates an arbovirus encephalitis by reducing viral titer, inflammation, and cellular infiltrates in the central nervous system.

Foo IJH, Chua BY, Chang SY, Jia X, van der Eerden A, Fazakerley JK, Kedzierska K, Kedzierski L. Foo IJH, et al. Among authors: chang sy. J Virol. 2025 Jan 16:e0210824. doi: 10.1128/jvi.02108-24. Online ahead of print. J Virol. 2025. PMID: 39817772

10

Atlas of Fshr expression from novel reporter mice.

Chen H, Fang HQ, Liu JT, Chang SY, Cheng LB, Sun MX, Feng JR, Liu ZM, Zhang YH, Rosen CJ, Liu P. Chen H, et al. Among authors: chang sy. Elife. 2025 Jan 8;13:RP93413. doi: 10.7554/eLife.93413. Elife. 2025. PMID: 39773308 Free PMC article.

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