Rainier JD - Search Results

1

Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore.

Martínez-Morales E, Kopljar I, Rainier JD, Tytgat J, Snyders DJ, Labro AJ. Martínez-Morales E, et al. Among authors: rainier jd. Toxicon. 2016 Sep 15;120:57-60. doi: 10.1016/j.toxicon.2016.07.017. Epub 2016 Jul 28. Toxicon. 2016. PMID: 27475861 Free PMC article.

2

The total synthesis of gambierol.

Johnson HW, Majumder U, Rainier JD. Johnson HW, et al. Among authors: rainier jd. J Am Chem Soc. 2005 Jan 26;127(3):848-9. doi: 10.1021/ja043396d. J Am Chem Soc. 2005. PMID: 15656618

3

TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning.

Cuypers E, Yanagihara A, Rainier JD, Tytgat J. Cuypers E, et al. Among authors: rainier jd. Biochem Biophys Res Commun. 2007 Sep 14;361(1):214-7. doi: 10.1016/j.bbrc.2007.07.009. Epub 2007 Jul 16. Biochem Biophys Res Commun. 2007. PMID: 17659256 Free PMC article.

4

Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels.

Cuypers E, Abdel-Mottaleb Y, Kopljar I, Rainier JD, Raes AL, Snyders DJ, Tytgat J. Cuypers E, et al. Among authors: rainier jd. Toxicon. 2008 May;51(6):974-83. doi: 10.1016/j.toxicon.2008.01.004. Epub 2008 Jan 12. Toxicon. 2008. PMID: 18313714 Free PMC article.

5

A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol.

Kopljar I, Labro AJ, Cuypers E, Johnson HW, Rainier JD, Tytgat J, Snyders DJ. Kopljar I, et al. Among authors: rainier jd. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9896-901. doi: 10.1073/pnas.0812471106. Epub 2009 May 29. Proc Natl Acad Sci U S A. 2009. PMID: 19482941 Free PMC article.

6

The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state.

Kopljar I, Labro AJ, de Block T, Rainier JD, Tytgat J, Snyders DJ. Kopljar I, et al. Among authors: rainier jd. J Gen Physiol. 2013 Mar;141(3):359-69. doi: 10.1085/jgp.201210890. Epub 2013 Feb 11. J Gen Physiol. 2013. PMID: 23401573 Free PMC article.

7

Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ oscillations in cerebrocortical neurons.

Cao Z, Cui Y, Busse E, Mehrotra S, Rainier JD, Murray TF. Cao Z, et al. Among authors: rainier jd. J Pharmacol Exp Ther. 2014 Sep;350(3):615-23. doi: 10.1124/jpet.114.215319. Epub 2014 Jun 23. J Pharmacol Exp Ther. 2014. PMID: 24957609 Free PMC article.

8

Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels.

Kopljar I, Grottesi A, de Block T, Rainier JD, Tytgat J, Labro AJ, Snyders DJ. Kopljar I, et al. Among authors: rainier jd. Neuropharmacology. 2016 Aug;107:160-167. doi: 10.1016/j.neuropharm.2016.03.010. Epub 2016 Mar 5. Neuropharmacology. 2016. PMID: 26956727 Free PMC article.

9

Synthesis of an F-H gambierol subunit using a C-glycoside-centered strategy.

Majumder U, Cox JM, Rainier JD. Majumder U, et al. Among authors: rainier jd. Org Lett. 2003 Mar 20;5(6):913-6. doi: 10.1021/ol034100w. Org Lett. 2003. PMID: 12633104

10

Total synthesis of gambierol: the generation of the A-C and F-H subunits by using a C-glycoside centered strategy.

Majumder U, Cox JM, Johnson HW, Rainier JD. Majumder U, et al. Among authors: rainier jd. Chemistry. 2006 Feb 8;12(6):1736-46. doi: 10.1002/chem.200500993. Chemistry. 2006. PMID: 16331718

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