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Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.
Martínez-Cisuelo V, Gómez J, García-Junceda I, Naudí A, Cabré R, Mota-Martorell N, López-Torres M, González-Sánchez M, Pamplona R, Barja G. Martínez-Cisuelo V, et al. Exp Gerontol. 2016 Oct;83:130-8. doi: 10.1016/j.exger.2016.08.002. Epub 2016 Aug 4. Exp Gerontol. 2016. PMID: 27498120
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