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Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I.
Dezfulian C, Shiva S, Alekseyenko A, Pendyal A, Beiser DG, Munasinghe JP, Anderson SA, Chesley CF, Vanden Hoek TL, Gladwin MT. Dezfulian C, et al. Circulation. 2009 Sep 8;120(10):897-905. doi: 10.1161/CIRCULATIONAHA.109.853267. Epub 2009 Aug 24. Circulation. 2009. PMID: 19704094 Free PMC article.
Nitrite therapy is neuroprotective and safe in cardiac arrest survivors.
Dezfulian C, Alekseyenko A, Dave KR, Raval AP, Do R, Kim F, Perez-Pinzon MA. Dezfulian C, et al. Nitric Oxide. 2012 May 15;26(4):241-50. doi: 10.1016/j.niox.2012.03.007. Epub 2012 Mar 30. Nitric Oxide. 2012. PMID: 22484664 Free PMC article. Clinical Trial.
Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes.
Jackson TC, Verrier JD, Drabek T, Janesko-Feldman K, Gillespie DG, Uray T, Dezfulian C, Clark RS, Bayir H, Jackson EK, Kochanek PM. Jackson TC, et al. Among authors: dezfulian c. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28. doi: 10.1124/jpet.113.206888. Epub 2013 Sep 10. J Pharmacol Exp Ther. 2013. PMID: 24023368 Free PMC article.
Effects of inhalation of low-dose nitrite or carbon monoxide on post-reperfusion mitochondrial function and tissue injury in hemorrhagic shock swine.
Haugaa H, Gómez H, Maberry DR, Holder A, Ogundele O, Quintero AM, Escobar D, Tønnessen TI, Airgood H, Dezfulian C, Kenny E, Shiva S, Zuckerbraun B, Pinsky MR. Haugaa H, et al. Among authors: dezfulian c. Crit Care. 2015 Apr 22;19(1):184. doi: 10.1186/s13054-015-0903-z. Crit Care. 2015. PMID: 25899004 Free PMC article.
107 results