Cleary Y - Search Results

1

Clinical Drug-Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor Alectinib.

Morcos PN, Cleary Y, Guerini E, Dall G, Bogman K, De Petris L, Viteri S, Bordogna W, Yu L, Martin-Facklam M, Phipps A. Morcos PN, et al. Among authors: cleary y. Clin Pharmacol Drug Dev. 2017 May;6(3):280-291. doi: 10.1002/cpdd.298. Epub 2016 Sep 28. Clin Pharmacol Drug Dev. 2017. PMID: 27545757 Clinical Trial.

2

Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non-Michaelis-Menten P450 Kinetics on Fraction Metabolized.

Fowler S, Guerini E, Qiu N, Cleary Y, Parrott N, Greig G, Mallalieu NL. Fowler S, et al. Among authors: cleary y. J Pharmacol Exp Ther. 2017 Jan;360(1):164-173. doi: 10.1124/jpet.116.237214. Epub 2016 Nov 7. J Pharmacol Exp Ther. 2017. PMID: 27821711 Clinical Trial.

3

Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.

Fowler S, Morcos PN, Cleary Y, Martin-Facklam M, Parrott N, Gertz M, Yu L. Fowler S, et al. Among authors: cleary y. Curr Pharmacol Rep. 2017;3(1):36-49. doi: 10.1007/s40495-017-0082-5. Epub 2017 Feb 1. Curr Pharmacol Rep. 2017. PMID: 28261547 Free PMC article. Review.

4

Model-Based Assessments of CYP-Mediated Drug-Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development.

Cleary Y, Gertz M, Morcos PN, Yu L, Youdim K, Phipps A, Fowler S, Parrott N. Cleary Y, et al. Clin Pharmacol Ther. 2018 Sep;104(3):505-514. doi: 10.1002/cpt.956. Epub 2017 Dec 27. Clin Pharmacol Ther. 2018. PMID: 29226313

5

Effect of Hepatic Impairment on the Pharmacokinetics of Alectinib.

Morcos PN, Cleary Y, Sturm-Pellanda C, Guerini E, Abt M, Donzelli M, Vazvaei F, Balas B, Parrott N, Yu L. Morcos PN, et al. Among authors: cleary y. J Clin Pharmacol. 2018 Dec;58(12):1618-1628. doi: 10.1002/jcph.1286. Epub 2018 Jul 27. J Clin Pharmacol. 2018. PMID: 30052269 Free PMC article.

6

A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier.

Sturm S, Günther A, Jaber B, Jordan P, Al Kotbi N, Parkar N, Cleary Y, Frances N, Bergauer T, Heinig K, Kletzl H, Marquet A, Ratni H, Poirier A, Müller L, Czech C, Khwaja O. Sturm S, et al. Among authors: cleary y. Br J Clin Pharmacol. 2019 Jan;85(1):181-193. doi: 10.1111/bcp.13786. Epub 2018 Nov 16. Br J Clin Pharmacol. 2019. PMID: 30302786 Free PMC article. Clinical Trial.

7

Model-Based Drug-Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy.

Cleary Y, Gertz M, Grimsey P, Günther A, Heinig K, Ogungbenro K, Aarons L, Galetin A, Kletzl H. Cleary Y, et al. Clin Pharmacol Ther. 2021 Dec;110(6):1547-1557. doi: 10.1002/cpt.2384. Epub 2021 Sep 1. Clin Pharmacol Ther. 2021. PMID: 34347881 Free PMC article.

8

Physiologically-Based Pharmacokinetic Modelling of Entrectinib Parent and Active Metabolite to Support Regulatory Decision-Making.

Djebli N, Buchheit V, Parrott N, Guerini E, Cleary Y, Fowler S, Frey N, Yu L, Mercier F, Phipps A, Meneses-Lorente G. Djebli N, et al. Among authors: cleary y. Eur J Drug Metab Pharmacokinet. 2021 Nov;46(6):779-791. doi: 10.1007/s13318-021-00714-z. Epub 2021 Sep 8. Eur J Drug Metab Pharmacokinet. 2021. PMID: 34495458

9

Accelerating Clinical Development of Idasanutlin through a Physiologically Based Pharmacokinetic Modeling Risk Assessment for CYP450 Isoenzyme-Related Drug-Drug Interactions.

Umehara K, Cleary Y, Fowler S, Parrott N, Tuerck D. Umehara K, et al. Among authors: cleary y. Drug Metab Dispos. 2022 Mar;50(3):214-223. doi: 10.1124/dmd.121.000720. Epub 2021 Dec 22. Drug Metab Dispos. 2022. PMID: 34937801

10

Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children.

Johnson TN, Cleary Y, Parrott N, Reigner B, Smith JR, Toovey S. Johnson TN, et al. Among authors: cleary y. Br J Clin Pharmacol. 2019 Jan;85(1):100-113. doi: 10.1111/bcp.13764. Epub 2018 Nov 5. Br J Clin Pharmacol. 2019. PMID: 30198595 Free PMC article.

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