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A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo.
Ohira M, Iwasaki Y, Tanaka C, Kuroki M, Matsuo N, Kitamura T, Yukuhiro M, Morimoto H, Pang N, Liu B, Kiyono T, Amemiya M, Tanaka K, Yoshida K, Sugimoto N, Ohshima T, Fujita M. Ohira M, et al. Among authors: yoshida k. Biochim Biophys Acta. 2015 Sep;1850(9):1676-84. doi: 10.1016/j.bbagen.2015.04.013. Epub 2015 May 7. Biochim Biophys Acta. 2015. PMID: 25960391
Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture.
Sugimoto N, Maehara K, Yoshida K, Yasukouchi S, Osano S, Watanabe S, Aizawa M, Yugawa T, Kiyono T, Kurumizaka H, Ohkawa Y, Fujita M. Sugimoto N, et al. Among authors: yoshida k. Nucleic Acids Res. 2015 Jul 13;43(12):5898-911. doi: 10.1093/nar/gkv509. Epub 2015 May 18. Nucleic Acids Res. 2015. PMID: 25990725 Free PMC article.
TRF2 recruits ORC through TRFH domain dimerization.
Higa M, Kushiyama T, Kurashige S, Kohmon D, Enokitani K, Iwahori S, Sugimoto N, Yoshida K, Fujita M. Higa M, et al. Among authors: yoshida k. Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):191-201. doi: 10.1016/j.bbamcr.2016.11.004. Epub 2016 Nov 9. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 27836746 Free article.
GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
Kayama K, Watanabe S, Takafuji T, Tsuji T, Hironaka K, Matsumoto M, Nakayama KI, Enari M, Kohno T, Shiraishi K, Kiyono T, Yoshida K, Sugimoto N, Fujita M. Kayama K, et al. Among authors: yoshida k. EMBO Rep. 2017 Jan;18(1):123-137. doi: 10.15252/embr.201642444. Epub 2016 Nov 17. EMBO Rep. 2017. PMID: 27856536 Free PMC article.
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