Martin NI - Search Results

1

A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase.

van Haren MJ, Sastre Toraño J, Sartini D, Emanuelli M, Parsons RB, Martin NI. van Haren MJ, et al. Among authors: martin ni. Biochemistry. 2016 Sep 20;55(37):5307-15. doi: 10.1021/acs.biochem.6b00733. Epub 2016 Sep 9. Biochemistry. 2016. PMID: 27570878

2

A concise preparation of the fluorescent amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine and extension of its utility in solid phase peptide synthesis.

Koopmans T, van Haren M, van Ufford LQ, Beekman JM, Martin NI. Koopmans T, et al. Among authors: martin ni. Bioorg Med Chem. 2013 Jan 15;21(2):553-9. doi: 10.1016/j.bmc.2012.10.055. Epub 2012 Nov 21. Bioorg Med Chem. 2013. PMID: 23238078

3

Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites.

van Haren M, van Ufford LQ, Moret EE, Martin NI. van Haren M, et al. Among authors: martin ni. Org Biomol Chem. 2015 Jan 14;13(2):549-60. doi: 10.1039/c4ob01734j. Org Biomol Chem. 2015. PMID: 25380215

4

New Insights into Nisin's Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues.

't Hart P, Oppedijk SF, Breukink E, Martin NI. 't Hart P, et al. Among authors: martin ni. Biochemistry. 2016 Jan 12;55(1):232-7. doi: 10.1021/acs.biochem.5b01173. Epub 2015 Dec 22. Biochemistry. 2016. PMID: 26653142

5

Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway.

Thomas MG, Sartini D, Emanuelli M, van Haren MJ, Martin NI, Mountford DM, Barlow DJ, Klamt F, Ramsden DB, Reza M, Parsons RB. Thomas MG, et al. Among authors: martin ni. Biochem J. 2016 Oct 1;473(19):3253-67. doi: 10.1042/BCJ20160219. Epub 2016 Jul 7. Biochem J. 2016. PMID: 27389312

6

Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase.

Sevšek A, Čelan M, Erjavec B, Quarles van Ufford L, Sastre Toraño J, Moret EE, Pieters RJ, Martin NI. Sevšek A, et al. Among authors: martin ni. Org Biomol Chem. 2016 Oct 7;14(37):8670-3. doi: 10.1039/c6ob01735e. Epub 2016 Sep 6. Org Biomol Chem. 2016. PMID: 27604065

7

Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.

Cura V, Marechal N, Troffer-Charlier N, Strub JM, van Haren MJ, Martin NI, Cianférani S, Bonnefond L, Cavarelli J. Cura V, et al. Among authors: martin ni. FEBS J. 2017 Jan;284(1):77-96. doi: 10.1111/febs.13953. Epub 2016 Nov 23. FEBS J. 2017. PMID: 27879050 Free article.

8

Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.

van Haren MJ, Marechal N, Troffer-Charlier N, Cianciulli A, Sbardella G, Cavarelli J, Martin NI. van Haren MJ, et al. Among authors: martin ni. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3625-3630. doi: 10.1073/pnas.1618401114. Epub 2017 Mar 22. Proc Natl Acad Sci U S A. 2017. PMID: 28330993 Free PMC article.

9

Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state.

van Haren MJ, Taig R, Kuppens J, Sastre Toraño J, Moret EE, Parsons RB, Sartini D, Emanuelli M, Martin NI. van Haren MJ, et al. Among authors: martin ni. Org Biomol Chem. 2017 Aug 9;15(31):6656-6667. doi: 10.1039/c7ob01357d. Org Biomol Chem. 2017. PMID: 28758655

10

A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C.

Kleijn LHJ, Vlieg HC, Wood TM, Sastre Toraño J, Janssen BJC, Martin NI. Kleijn LHJ, et al. Among authors: martin ni. Angew Chem Int Ed Engl. 2017 Dec 22;56(52):16546-16549. doi: 10.1002/anie.201709240. Epub 2017 Nov 30. Angew Chem Int Ed Engl. 2017. PMID: 29108098 Free PMC article.

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