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Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.
Nys M, Wijckmans E, Farinha A, Yoluk Ö, Andersson M, Brams M, Spurny R, Peigneur S, Tytgat J, Lindahl E, Ulens C. Nys M, et al. Among authors: lindahl e. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6696-E6703. doi: 10.1073/pnas.1603101113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791038 Free PMC article.
Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.
Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. Ma J, et al. Among authors: lindahl e. Cancer Cell. 2019 Mar 18;35(3):504-518.e7. doi: 10.1016/j.ccell.2019.01.020. Epub 2019 Feb 28. Cancer Cell. 2019. PMID: 30827889 Free PMC article.
Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope.
Orellana L, Thorne AH, Lema R, Gustavsson J, Parisian AD, Hospital A, Cordeiro TN, Bernadó P, Scott AM, Brun-Heath I, Lindahl E, Cavenee WK, Furnari FB, Orozco M. Orellana L, et al. Among authors: lindahl e. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10009-10018. doi: 10.1073/pnas.1821442116. Epub 2019 Apr 26. Proc Natl Acad Sci U S A. 2019. PMID: 31028138 Free PMC article.
199 results