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Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase.
González MM, Kosmopoulou M, Mojica MF, Castillo V, Hinchliffe P, Pettinati I, Brem J, Schofield CJ, Mahler G, Bonomo RA, Llarrull LI, Spencer J, Vila AJ. González MM, et al. Among authors: brem j. ACS Infect Dis. 2015 Nov 13;1(11):544-54. doi: 10.1021/acsinfecdis.5b00046. Epub 2015 Jul 20. ACS Infect Dis. 2015. PMID: 27623409 Free PMC article.
Assay platform for clinically relevant metallo-β-lactamases.
van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. van Berkel SS, et al. Among authors: brem j. J Med Chem. 2013 Sep 12;56(17):6945-53. doi: 10.1021/jm400769b. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23898798 Free PMC article.
Binding of (5S)-penicilloic acid to penicillin binding protein 3.
van Berkel SS, Nettleship JE, Leung IK, Brem J, Choi H, Stuart DI, Claridge TD, McDonough MA, Owens RJ, Ren J, Schofield CJ. van Berkel SS, et al. Among authors: brem j. ACS Chem Biol. 2013 Oct 18;8(10):2112-6. doi: 10.1021/cb400200h. Epub 2013 Aug 15. ACS Chem Biol. 2013. PMID: 23899657
93 results