A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models.
Stennicke HR, Kjalke M, Karpf DM, Balling KW, Johansen PB, Elm T, Øvlisen K, Möller F, Holmberg HL, Gudme CN, Persson E, Hilden I, Pelzer H, Rahbek-Nielsen H, Jespersgaard C, Bogsnes A, Pedersen AA, Kristensen AK, Peschke B, Kappers W, Rode F, Thim L, Tranholm M, Ezban M, Olsen EH, Bjørn SE.
Stennicke HR, et al. Among authors: olsen eh.
Blood. 2013 Mar 14;121(11):2108-16. doi: 10.1182/blood-2012-01-407494. Epub 2013 Jan 18.
Blood. 2013.
PMID: 23335368
Free PMC article.