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Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions.
Gesing A, Masternak MM, Wang F, Joseph AM, Leeuwenburgh C, Westbrook R, Lewinski A, Karbownik-Lewinska M, Bartke A. Gesing A, et al. J Gerontol A Biol Sci Med Sci. 2011 Oct;66(10):1062-76. doi: 10.1093/gerona/glr080. Epub 2011 Jul 25. J Gerontol A Biol Sci Med Sci. 2011. PMID: 21788651 Free PMC article.
Metabolic effects of intra-abdominal fat in GHRKO mice.
Masternak MM, Bartke A, Wang F, Spong A, Gesing A, Fang Y, Salmon AB, Hughes LF, Liberati T, Boparai R, Kopchick JJ, Westbrook R. Masternak MM, et al. Among authors: gesing a. Aging Cell. 2012 Feb;11(1):73-81. doi: 10.1111/j.1474-9726.2011.00763.x. Epub 2011 Nov 28. Aging Cell. 2012. PMID: 22040032 Free PMC article.
Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.
Gesing A, Masternak MM, Lewinski A, Karbownik-Lewinska M, Kopchick JJ, Bartke A. Gesing A, et al. J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):639-51. doi: 10.1093/gerona/gls231. Epub 2012 Nov 29. J Gerontol A Biol Sci Med Sci. 2013. PMID: 23197187 Free PMC article.
61 results