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Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.
Rohrbeck L, Gong JN, Lee EF, Kueh AJ, Behren A, Tai L, Lessene G, Huang DC, Fairlie WD, Strasser A, Herold MJ. Rohrbeck L, et al. Among authors: kueh aj. Cell Death Differ. 2016 Dec;23(12):2054-2062. doi: 10.1038/cdd.2016.96. Epub 2016 Sep 30. Cell Death Differ. 2016. PMID: 27689874 Free PMC article.
A non-canonical function of Ezh2 preserves immune homeostasis.
Vasanthakumar A, Xu D, Lun AT, Kueh AJ, van Gisbergen KP, Iannarella N, Li X, Yu L, Wang D, Williams BR, Lee SC, Majewski IJ, Godfrey DI, Smyth GK, Alexander WS, Herold MJ, Kallies A, Nutt SL, Allan RS. Vasanthakumar A, et al. Among authors: kueh aj. EMBO Rep. 2017 Apr;18(4):619-631. doi: 10.15252/embr.201643237. Epub 2017 Feb 21. EMBO Rep. 2017. PMID: 28223321 Free PMC article.
DR5 and caspase-8 are dispensable in ER stress-induced apoptosis.
Glab JA, Doerflinger M, Nedeva C, Jose I, Mbogo GW, Paton JC, Paton AW, Kueh AJ, Herold MJ, Huang DC, Segal D, Brumatti G, Puthalakath H. Glab JA, et al. Among authors: kueh aj. Cell Death Differ. 2017 May;24(5):944-950. doi: 10.1038/cdd.2017.53. Epub 2017 Apr 14. Cell Death Differ. 2017. PMID: 28409774 Free PMC article.
CRISPR/Cas9: A tool for immunological research.
Hochheiser K, Kueh AJ, Gebhardt T, Herold MJ. Hochheiser K, et al. Among authors: kueh aj. Eur J Immunol. 2018 Apr;48(4):576-583. doi: 10.1002/eji.201747131. Epub 2018 Feb 26. Eur J Immunol. 2018. PMID: 29415333 Free article. Review.
Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.
O'Reilly LA, Putoczki TL, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, Griffin MDW, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A. O'Reilly LA, et al. Immunity. 2018 Mar 20;48(3):570-583.e8. doi: 10.1016/j.immuni.2018.03.003. Immunity. 2018. PMID: 29562203 Free article.
79 results